ArticlePloS one2022
Modelling of filamentous phage-induced antibiotic tolerance of P. aeruginosa.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Study of the probability of resistance to phage infection in a collection of clinical isolates ofMicrobiology spectrum · 2025Article
- Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding.Science advances · 2024Article
- Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding.bioRxiv : the preprint server for biology · 2024Article
- Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The biofilm community resurfaces: new findings and post-pandemic progress.Journal of bacteriology · 2023Review
- Heterogenous Biofilm Mass-Transport Model Replicates Periphery Sequestration of Antibiotics inbioRxiv : the preprint server for biology · 2023Article
- Homogenization modelling of antibiotic diffusion and adsorption in viral liquid crystals.Royal Society open science · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous molecules tend to spontaneously assemble into liquid crystalline droplets with a tactoid morphology in environments with high concentration on non-adsorbing molecules. Tactoids of filamentous Pf bacteriophage, such as those produced by Pseudomonas aeruginosa, have been linked to increased antibiotic tolerance. We modelled this system and show that tactoids composed of filamentous Pf virions can lead to antibiotic tolerance by acting as an adsorptive diffusion barrier. The continuum model, reminiscent of descriptions of reactive diffusion in porous media, has been solved numerically and good agreement was found with the analytical results, obtained using a homogenisation approach. We find that the formation of tactoids significantly increases antibiotic diffusion times which may lead to stronger antibiotic resistance.
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Registered trials
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