Evidence map›Paper›PMID 35404616›Full record

ArticleJournal of medicinal chemistry2022

Screening of σ

Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Aladdin Riad, Nicholas J Izzo, Susan M Catalano, Thomas J A Graham, Robert H Mach

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Frontiers in neuroscience · 2024
    Article
  4. Development and Optimization ofACS pharmacology & translational science · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Diagnostic and Therapeutic Radiopharmaceuticals.ACS pharmacology & translational science · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ho Young KimDepartment of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0003-4391-9642
Ji Youn LeeDepartment of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Chia-Ju HsiehDepartment of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-2833-7727
Aladdin RiadDepartment of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-0525-446X
Nicholas J IzzoCognition Therapeutics Inc., Pittsburgh, Pennsylvania 15203-5118, United States.ORCID 0000-0002-0196-2055
Susan M CatalanoCognition Therapeutics Inc., Pittsburgh, Pennsylvania 15203-5118, United States.
Thomas J A GrahamDepartment of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Robert H MachDepartment of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-7645-2869
University of Pennsylvania · USCognition Therapeutics (United States) · US

Funding

Optimization of sigma-2 receptor modulators for the treatment of cognitive dysfunctionR42AG052249 · NIA · COGNITION THERAPEUTICS, INC. · PI IZZO, NICHOLAS JOHN · 2018 to 2019
$2.1M
NIA NIH HHS R42 AG052249
6 · The paper itself

Abstract

In this study, a panel of 46 compounds containing five different scaffolds known to have high σ

Indexed as

Receptors, sigmaTetrahydroisoquinolinesBrainLigandsPositron-Emission TomographyRadiopharmaceuticalsLigandsRadiopharmaceuticalsReceptors, sigmaTetrahydroisoquinolines

Identifiers

PMID35404616
PMCPMC13012568
OpenAlexW4223481668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.