Evidence map›Paper›PMID 35404236›Full record

ArticleeLife2022

Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians.

David R Shook, Jason W H Wen, Ana Rolo, Michael O'Hanlon, Brian Francica, Destiny Dobbins, Paul Skoglund, Douglas W DeSimone, Rudolf Winklbauer, Ray E Keller

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Functional genomics iniScience · 2026
    Article
  2. Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Convergent extension in the amphibian, Xenopus laevis.Current topics in developmental biology · 2020
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

David R ShookDepartment of Biology, University of Virginia, Charlottesville, United States.ORCID 0000-0002-0131-1834
Jason W H WenDepartment of Cell and Systems Biology, University of Toronto, Toronto, Canada.ORCID 0000-0001-7402-5073
Ana RoloCentre for Craniofacial and Regenerative Biology, King's College London, London, United Kingdom.
Michael O'HanlonDepartment of Cell Biology, University of Virginia, School of Medicine, Charlottesville, United States.
Brian FrancicaAduro Biotech, Berkeley, United States.
Destiny DobbinsIndependent researcher, Philadelphia, United States.
Paul SkoglundDepartment of Biology, University of Virginia, Charlottesville, United States.
Douglas W DeSimone *Department of Cell Biology, University of Virginia, School of Medicine, Charlottesville, United States.ORCID 0000-0003-1926-1588
Rudolf Winklbauer *Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.ORCID 0000-0002-0628-0897
Ray E Keller *Department of Biology, University of Virginia, Charlottesville, United States.ORCID 0000-0001-5686-1959
University of Virginia · USUniversity of Toronto · CAAduro BioTech (United States) · USKing's College London · GB

Funding

Cell-Cell and Cell-Matrix Interactions in MorphogenesisR01GM094793 · NIGMS · UNIVERSITY OF VIRGINIA · PI DESIMONE, DOUGLAS W. · 2010 to 2017
$3.3M
CELL MOTILITY AND CELL INTERACTIONS DURING NEURULATIONR37HD025594 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KELLER, RAYMOND E · 1998 to 2011
$3.3M
Cell-Cell and Cell-Matrix Interactions in MorphogenesisR35GM131865 · NIGMS · UNIVERSITY OF VIRGINIA · PI DESIMONE, DOUGLAS W. · 2019 to 2023
$2.2M
Regulation of Axial Extension in Vertebrate EmbryosR01GM099108 · NIGMS · UNIVERSITY OF VIRGINIA · PI SKOGLUND, PAUL MICHAEL · 2012 to 2015
$1.2M
MULTIPHOTON SPECTRAL IMAGING MICROSCOPY: NEUROSCIENCE, TAU PROTEIN, &TBI RESS10RR021202 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PERIASAMY, AMMASI · 2005 to 2005
$500k
NCRR NIH HHS S10 RR021202NICHD NIH HHS R37 HD025594NIGMS NIH HHS R01 GM094793NIGMS NIH HHS R01 GM099108NIGMS NIH HHS R35 GM131865
6 · The paper itself

Abstract

The morphogenic process of convergent thickening (CT) was originally described as the mediolateral convergence and radial thickening of the explanted ventral involuting marginal zone (IMZ) of

Indexed as

Biological EvolutionGastrulaAnimalsCell MovementMorphogenesisXenopus laevisbiomechanicsblastopore closureconvergent thickeningdevelopmental biologygastrulationmorphogenesisphysics of living systemstissue surface tensionxenopus

Identifiers

PMID35404236
PMCPMC9064293
OpenAlexW4225405087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.