Evidence map›Paper›PMID 35404079›Full record

ArticleMicrobiology spectrum2022

A G-Protein-Coupled Receptor Modulates Gametogenesis via PKG-Mediated Signaling Cascade in Plasmodium berghei.

Peng-Peng Wang, Xuefeng Jiang, Liying Zhu, Dan Zhou, Mingyang Hong, Lu He, Lumeng Chen, Shijie Yao, Yan Zhao, Guang Chen and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. mBio · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Microorganisms · 2023
    Review
  11. Article
  12. Article
  13. Gametogenesis inFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Peng-Peng Wang *Department of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Xuefeng Jiang *Department of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Liying ZhuDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Dan ZhouDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Mingyang HongDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Lu HeDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Lumeng ChenDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Shijie YaoDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Yan ZhaoDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Guang ChenDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Chengqi WangDepartment of Internal Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Liwang CuiDepartment of Internal Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.ORCID 0000-0002-8338-1974
Yaming CaoDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.
Xiaotong ZhuDepartment of Immunology, College of Basic Medical Sciences, China Medical Universitygrid.254145.3, Shenyang, China.ORCID 0000-0002-9064-586X
China Medical University · CNUniversity of South Florida · USTaizhou University · CN

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
Antigen discovery for transmission-blocking vaccines in Plasmodium vivaxR01AI150533 · NIAID · CHINA MEDICAL UNIVERSITY · PI CAO, YAMING · 2020 to 2024
$677k
NIAID NIH HHS R01 AI150533NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Gametogenesis is essential for malaria parasite transmission, but the molecular mechanism of this process remains to be refined. Here, we identified a G-protein-coupled receptor 180 (GPR180) that plays a critical role in signal transduction during gametogenesis in

Indexed as

CulicidaeMalariaParasitesAnimalsCyclic GMP-Dependent Protein KinasesFemaleGametogenesisHumansPlasmodium bergheiPlasmodium falciparumProtozoan ProteinsReceptors, G-Protein-CoupledSignal TransductionCyclic GMP-Dependent Protein KinasesProtozoan ProteinsReceptors, G-Protein-CoupledgametogenesisG-protein-coupled receptormalariasignal transductiontransmission-blocking activity

Identifiers

PMID35404079
PMCPMC9045217
OpenAlexW4223459708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.