Evidence map›Paper›PMID 35404053›Full record

ArticleJournal of medicinal chemistry2022

Demonstration of a Common DPhe

Luis E Gimenez, Terry A Noblin, Savannah Y Williams, Satarupa Mullick Bagchi, Ren-Lei Ji, Ya-Xiong Tao, Claus B Jeppesen, Kilian W Conde-Frieboes, Tomi K Sawyer, Paolo Grieco and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Luis E GimenezLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Terry A NoblinLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Savannah Y WilliamsLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Satarupa Mullick BagchiLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Ren-Lei JiDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, United States.
Ya-Xiong TaoDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, United States.ORCID 0000-0003-4737-749X
Claus B JeppesenGlobal Drug Discovery, Novo Nordisk A/S, 2760 Måløv, Denmark.
Kilian W Conde-FrieboesGlobal Research Technology, Novo Nordisk A/S, 2760 Måløv, Denmark.ORCID 0000-0001-5303-4448
Tomi K SawyerCourage Therapeutics, 64 Homer Street, Newton, Massachusetts 02459, United States.
Paolo Grieco
Roger D ConeLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-3333-5651
University of Michigan · USAuburn University · USNovo Nordisk (Denmark) · DKCentro Interuniversitario di Ricerca sui Peptidi Bioattivi · IT

Funding

Development of Novel Melanocortin-4 Receptor Peptide Agonists for the Treatment ofMC4R HaploinsufficiencyR42DK127817 · NIDDK · COURAGE THERAPEUTICS, INC. · PI SAWYER, TOMI K · 2022 to 2023
$1.7M
Sexually Dimorphic Expression and Function of the Melanocortin-3 ReceptorR01DK126715 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CONE, ROGER D. · 2020 to 2022
$1.0M
Development of Melanocortin-3 Receptor Peptide Agonists for the Treatment of Anorexia NervosaR41MH124449 · NIMH · COURAGE THERAPEUTICS, INC. · PI SAWYER, TOMI K · 2021 to 2021
$251k
Development of Melanocortin-3 Receptor Peptide Antagonists for the Treatment of Obesity and Maintenance of Weight LossR41DK127817 · NIDDK · COURAGE THERAPEUTICS, INC. · PI SAWYER, TOMI K · 2020 to 2020
$245k
NIDDK NIH HHS R01 DK126715NIDDK NIH HHS R41 DK127817NIDDK NIH HHS R42 DK127817NIMH NIH HHS R41 MH124449
6 · The paper itself

Abstract

Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2')

Indexed as

MelanocortinsReceptors, CorticotropinAlanineHEK293 CellsHumansLigandsPeptidesReceptor, Melanocortin, Type 3Structure-Activity RelationshipAlanineLigandsMelanocortinsPeptidesReceptor, Melanocortin, Type 3Receptors, Corticotropin

Identifiers

PMID35404053
PMCPMC9059122
OpenAlexW4226116517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.