ArticleJournal of medicinal chemistry2022
Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors
Open access · hybridAbstract read
In one paragraph
Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Reconstruction of septin higher-order nano-size structures in ovarian cancer cells uncover susceptibility to the septin-targeting small molecule UR214-9.bioRxiv : the preprint server for biology · 2026Article
- Calcitriol is involved in maintaining primordial follicle reserve through the inhibition of the PI3K/Akt signaling pathway.Journal of ovarian research · 2026Article
- Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- VDR Decrease Enhances the Efficacy of 1,25-Dihydroxyvitamin D3 Inhibiting Gefitinib Resistance by Regulating EGFR/FASN Loop in NSCLC Cells.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Targeting Transient Receptor Potential Melastatin-2 (TRPM2) Enhances Therapeutic Efficacy of Third Generation EGFR Inhibitors against EGFR Mutant Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Exercise-induced vitamin D receptor and androgen receptor mediate inhibition of IL-6 and STAT3 in muscle.Biochemistry and biophysics reports · 2024Article
- Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.Cancers · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 9 institutions in 3 countries.
Negar KhazanWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Kyu Kwang KimWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Jeanne N HansenDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, United States.
Niloy A SinghWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Taylor MooreWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Cameron W A SnyderWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Ravina PanditaWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Myla StrawdermanDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14624, United States.
Michiko FujiharaDivision of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8530, Japan.
Yuta TakamuraDivision of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8530, Japan.ORCID 0000-0001-9799-7123
Ye JianDivision of Surgery and of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14624, United States.
Nicholas BattagliaDivision of Surgery and of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14624, United States.
Naohiro YanoDepartment of Surgery, Division of Surgical Research, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, United States.
Yuki TeramotoDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14624, United States.
Leggy A ArnoldDepartment of Chemistry and Biochemistry, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0003-1411-1572
Russell HopsonDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Keshav KishorDepartment of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, India.ORCID 0000-0003-0518-0971
Sneha NayakDepartment of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, India.ORCID 0000-0002-5571-4727
Debasmita OjhaDepartment of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, India.
Ashoke SharonDepartment of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, India.ORCID 0000-0001-5738-1607
John M AshtonGenomics Core Facility, Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14624, United States.
Jian WangDepartment of Pharmacology and Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Penn State University, Hershey, Pennsylvania 17036, United States.
Michael T MilanoDepartment of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 16424, United States.
Hiroshi MiyamotoDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14624, United States.ORCID 0000-0001-7610-7769
David C LinehanDivision of Surgery and of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14624, United States.
Scott A GerberDivision of Surgery and of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14624, United States.
Nada KawarCenter for Breast Health and Gynecologic Oncology, Mercy Medical Center, 271 Carew Street, Springfield, Massachusetts 01104, United States.
Ajay P SinghRutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, New Jersey 08019, United States.
Erdem D TabdanovCytoMechanobiology Laboratory, Department of Pharmacology, Penn State College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17036, United States.ORCID 0000-0003-2673-112X
Nikolay V DokholyanDepartment of Pharmacology and Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Penn State University, Hershey, Pennsylvania 17036, United States.
Hiroki KakutaDivision of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8530, Japan.ORCID 0000-0002-3633-8121
Peter W JurutkaSchool of Mathematical and Natural Sciences, Arizona State University, Health Futures Center, Phoenix, Arizona 85054, United States.
Nina F SchorDepartments of Pediatrics, Neurology, and Neuroscience, University of Rochester Medical Center, Rochester, New York 14642, United States.ORCID 0000-0002-3817-7376
Rachael B Rowswell-TurnerWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
Rakesh K SinghWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.ORCID 0000-0002-1124-9202
Richard G MooreWilmot Cancer Institute and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester New York 14624, United States.
University of Rochester Medical Center · USBirla Institute of Technology, Mesra · INOkayama University · JPPennsylvania State University · USBrown University · USMercy Medical Center · USRutgers, The State University of New Jersey · USUniversity of Arizona · USUniversity of Wisconsin–Milwaukee · US
Funding
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6MNanoscale programming of cellular and physiological phenotypes: EquipmentR35GM134864 · NIGMS · UNIVERSITY OF VIRGINIA · PI Nikolay Dokholyan · 2020 to 2026
$5.2MDiscovery of functionally selective dopamine ligands for age-related cognitive declineRF1AG071675 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DOKHOLYAN, NIKOLAY, MAILMAN, RICHARD B · 2021 to 2021
$1.5MNCATS NIH HHS UL1 TR002001NIA NIH HHS RF1 AG071675NIGMS NIH HHS R35 GM134864
Abstract
Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to inhibit tumors that overexpress VDR. However, the current antagonists are arduous to synthesize and are only partial antagonists, limiting their use. Here, we show that the VDR antagonist MeTC7 (
Indexed as
NeuroblastomaReceptors, CalcitriolAnimalsAnimals, Genetically ModifiedHeterograftsHumansVitaminsReceptors, CalcitriolVitamins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.