Evidence map›Paper›PMID 35404011›Full record

SynthesisActa parasitologica2022

Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review.

Palak Gupta, Kiran Kumari Singh, Ashutosh Balodhi, Khushi Jain, Farah Deeba, Nasir Salam

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Acta parasitologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Epidemiology, risk factors, and clinical characteristics of amoebic liver abscess: a systematic review and meta-analysis from India.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Recent developments in waterborne pathogen detection technologies.Environmental monitoring and assessment · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Interleukin 10 (IL-10) Production and Seroprevalence ofPathogens (Basel, Switzerland) · 2022
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Palak GuptaDepartment of Microbiology, Central University of Punjab, Bathinda, Punjab, 151401, India.
Kiran Kumari SinghDepartment of Geography, Central University of Punjab, Bathinda, Punjab, 151401, India.
Ashutosh BalodhiDepartment of Microbiology, Central University of Punjab, Bathinda, Punjab, 151401, India.
Khushi JainDepartment of Microbiology, Central University of Punjab, Bathinda, Punjab, 151401, India.
Farah DeebaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India.
Nasir SalamDepartment of Microbiology, Central University of Punjab, Bathinda, Punjab, 151401, India. salamnasir@gmail.com.ORCID http://orcid.org/0000-0001-9133-1304
Central University of Punjab · INJamia Millia Islamia · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntestinal protozoan parasites are responsible for diarrheal diseases causing significant morbidity and mortality. Entamoeba histolytica is the principle protozoan parasite associated with diarrheal infections. The infection is often associated with inaccessibility to clean drinking water and poor sanitary conditions in low- and middle-income countries including India. A comprehensive systematic review was performed to evaluate a reliable nationwide estimate for prevalence and geographic distribution of amoebiasis in India and the complications associated with it.

methodsWe used the PRISMA guidelines to perform a systematic review and meta-analysis of articles published between the year 2001-2020. Two English language databases PubMed and Web of Science were searched to achieve relevant studies.

resultsInitial searches resulted in 467 studies out of which 64 eligible articles involving data from 289,659 human subjects from 12 states and 4 union territories were included in the final analysis. Prevalence of amoebiasis ranged from 3-23% in asymptomatic population, 0.64-11% in symptomatic patients and 1-17.5% in HIV-infected patients. Highest prevalence was seen in Tamil Nadu, Andaman Nicobar Island and North East India. Extra intestinal invasion of Entamoeba histolytica leading to complications such as amoebic liver abscess, amoebic colitis, colonic perforation and ameboma were also reported. Such complications have the potential to increase healthcare burden and may prove to be fatal.

conclusionAmoebiasis remains a significant public health issue in India responsible for diarrheal diseases causing significant morbidity and mortality. Entamoeba histolytica is the principle protozoan parasite associated with amoebiasis. Public health efforts should be directed towards its control and better diagnostic methods should be employed for distinguishing between pathogenic and non-pathogenic species of Entamoeba.

Indexed as

AmebiasisEntamoeba histolyticaLiver Abscess, AmebicDiarrheaHumansIndiaPrevalenceAmoebiasisAmoebic liver abscessEntamoebaIndiaPrevalence

Identifiers

PMID35404011
OpenAlexW4223556545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.