Evidence map›Paper›PMID 35403874›Full record

ArticleWorld journal of surgery2022

Complications in Distal Pancreatectomy versus Radical Antegrade Modular Pancreatosplenectomy: A Disease Risk Score Analysis Utilizing National Surgical Quality Improvement Project Data.

Thomas L Sutton, Kristin C Potter, Skye C Mayo, Rodney Pommier, Erin W Gilbert, Brett C Sheppard

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in World journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05939063 (Laparoscopic Radical Antegrade Modular Pancreatosplenectomy Versus Laparoscopic Distal Pancreatosplecnectomy in Selected Left-sided Pancreatic Cancer), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05939063 narecruitingnot on this mapstarted 2023, after this paper: background citation

Laparoscopic Radical Antegrade Modular Pancreatosplenectomy Versus Laparoscopic Distal Pancreatosplecnectomy in Selected Left-sided Pancreatic Cancer: a Multicenter Randomized Controlled Clinical Trial

TypeinterventionalSponsorFudan UniversityRan2023 to 2028Enrolled160ConditionsLeft-sided Pancreatic CancerArmsLRAMPS, LDP
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thomas L SuttonDepartment of Surgery, Oregon Heath & Science University (OHSU), Portland, OR, 97239, USA.ORCID 0000-0002-2894-7154
Kristin C PotterSchool of Medicine, OHSU, Portland, OR, 97239, USA.
Skye C MayoDepartment of Surgery, Division of Surgical Oncology, OHSU, Portland, OR, 97239, USA.
Rodney PommierDepartment of Surgery, Division of Surgical Oncology, OHSU, Portland, OR, 97239, USA.
Erin W GilbertDepartment of Surgery, Oregon Heath & Science University (OHSU), Portland, OR, 97239, USA.
Brett C SheppardDepartment of Surgery, Oregon Heath & Science University (OHSU), Portland, OR, 97239, USA. sheppard@ohsu.edu.
Oregon Health & Science University · USPortland State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRadical antegrade modular pancreatosplenectomy (RAMPS) was developed to improve R0 resections and lymph node harvests versus distal pancreatectomy (DP) in pancreatic adenocarcinoma (PDAC); relative complication rates are understudied.

methodsPatients undergoing distal pancreas resections from 2006 to 2020 were identified from our institutional NSQIP database, grouped by resection method, and evaluated for the following outcomes: postoperative pancreatic fistula (POPF), clinically relevant POPF (crPOPF), incisional surgical site infection (iSSI), organ space SSI (osSSI), and Clavien-Dindo grade ≥ 3 (CD ≥ 3) complications using logistic regression. Patients were matched 1:1 based on disease risk score.

resultsTwo-hundred-thirty-six and 117 patients underwent DP and RAMPS, respectively. POPF, crPOPF, CD ≥ 3 complications, iSSI, and osSSIs occurred in 105 (30%), 43 (12%), 74 (21%), 34 (10%) and 52 (15%) patients, respectively. Disease risk score matching yielded 89 similar patients per group. On multivariable analysis, patients undergoing RAMPS were not significantly more likely to experience POPF (OR 0.69, P = 0.26), crPOPF (OR 0.41, P = 0.72), CD ≥ 3 complication (OR 0.78, P = 0.44), iSSI (OR 0.58, P = 0.27), or osSSI (OR 0.93, P = 0.86). Of patients with PDAC (n = 108) mean nodal harvest were 14.8 (SD 11.30) and 19.4 (SD 7.19) nodes for patients undergoing DP and RAMPS, respectively (P = 0.01). Six patients (20%) undergoing DP had positive margins versus 12 (15%) undergoing RAMPS (P = 0.56). At a median follow-up of 17 months, there was no difference in locoregional recurrence-free survival (P = 0.32) or overall survival (P = 0.92) on Kaplan-Meier analysis.

conclusionRAMPS does not result in increased complications compared to DP and routine use is encouraged in pancreatic malignancies.

Indexed as

AdenocarcinomaPancreatic NeoplasmsHumansPancreatectomyQuality ImprovementRetrospective StudiesRisk FactorsSplenectomy

Identifiers

PMID35403874
OpenAlexW4223416310

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.