Evidence map›Paper›PMID 35403869›Full record

ArticleActa neuropathologica2022

Somatic LINE-1 promoter acquisition drives oncogenic FOXR2 activation in pediatric brain tumor.

Diane A Flasch, Xiaolong Chen, Bensheng Ju, Xiaoyu Li, James Dalton, Heather L Mulder, John Easton, Lu Wang, Suzanne J Baker, Jason Chiang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Acta neuropathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. LINE-1 retrotransposition is a recurrent cause ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Diane A Flasch *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xiaolong Chen *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bensheng JuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xiaoyu LiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
James DaltonDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Heather L MulderDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lu WangDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Suzanne J BakerDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jason ChiangDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. Jason.Chiang@stjude.org.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. Jinghui.Zhang@stjude.org.ORCID 0000-0003-3350-9682
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
The DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0M
Discovery of Somatic Noncoding Variants that Serve as Drivers in Pediatric CancersR01CA216391 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZHANG, JINGHUI · 2018 to 2022
$2.8M
NCI NIH HHS P01 CA096832NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA216391
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain NeoplasmsChildForkhead Transcription FactorsHumansLong Interspersed Nucleotide ElementsPromoter Regions, GeneticForkhead Transcription FactorsFOXR2 protein, human

Identifiers

PMID35403869
PMCPMC9038871
OpenAlexW4223584506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.