ArticleInternational endodontic journal2022
Periapical and endodontic status of patients with inflammatory bowel disease: Age- and sex-matched case-control study.
Article in International endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- A systematic review and network meta-analysis of the association between periodontitis and inflammatory bowel diseases.BMC oral health · 2025Pooled it
- Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level.Frontiers in dental medicine · 2025Pooled it
- The Potential Association Between Inflammatory Bowel Diseases and Apical Periodontitis: A Systematic Review and Meta-Analysis.European endodontic journal · 2024Pooled it
- Outcomes of Root Canal Treatment in Patients With Autoimmune Disease: A Retrospective Case-Control Study.International endodontic journal · 2026Article
- Endodontic Inflammatory Disease: Systemic Consequences.Advances in experimental medicine and biology · 2026Review
- Does Diabetes Increase the Frequency of Root-Filled teeth: Systematic Review and Meta-Analysis of Observational Studies.Journal of clinical and experimental dentistry · 2023Review
- Sol-Gel Technologies to Obtain Advanced Bioceramics for Dental Therapeutics.Molecules (Basel, Switzerland) · 2023Review
- Interaction between apical periodontitis and systemic disease (Review).International journal of molecular medicine · 2023Review
- The Link between Stroke Risk and Orodental Status-A Comprehensive Review.Journal of clinical medicine · 2022Review
- Periapical and endodontic status of patients with inflammatory bowel disease: Age- and sex-matched case-control study.International endodontic journal · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimCrohn's disease (CD) and ulcerative colitis (UC) are two chronic recurrent inflammatory processes of the gastrointestinal tract, grouped under the name inflammatory bowel disease (IBD), causing clinical episodes of intestinal inflammation. The aim of this study was to investigate the possible association between IBD and the prevalence of apical periodontitis (AP) and root canal treatment. METHODOLOGY: A case-control study design matched to age and sex was used. The study group (SG) included 28 patients with IBD (13 with CD, 15 with UC). Another 28 healthy subjects, without IBD and age- and sex-matched, were included in the control group (CG). Radiographic records were analysed and AP was diagnosed as radiolucent periapical lesions (RPLs), using the periapical index score. Student's t-test, χ
resultsIn the CG, only 17 subjects (61%) had at least one tooth with AP, whilst in the SG group they were 23 patients (82%; OR = 2.98; 95% CI = 0.87-10.87; p = .08). The number of subjects with one or more root filled teeth (RFT) in the CG was 14 (50%), whilst in the SG they were 22 (79%; OR = 3.67; 95% CI = 1.14-11.79; p = .026). At least one RFT with AP was evident in three subjects (10.7%) in the CG, whilst in the SG 15 patients (53.6%) showed RFT with AP (OR = 9.60; 95% CI = 2.35-39.35; p = .001). In the multivariate logistic regression analysis, only endodontic status was found to be associated with IBD (OR = 1.86; 95% CI = 1.24-2.80; p = .003).
conclusionIBD, UC and Crohn's disease are associated with higher prevalence of RFT and higher percentage of RFT with periapical lesions. Dentists should consider these findings when caring for IBD patients by monitoring the evolution of periapical lesions of endodontically treated teeth.
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