ArticleRenal failure2022
Intraoperative vasopressor use and early postoperative acute kidney injury in elderly patients undergoing elective noncardiac surgery.
Article in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of esketamine on postinduction hypotension in elderly patients undergoing elective noncardiac surgery: a secondary analysis of a randomized clinical trial.Scientific reports · 2025Trial
- Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial.British journal of anaesthesia · 2024Trial
- Physiology, monitoring, and optimisation of perioperative tissue oxygenation: a narrative review.British journal of anaesthesia · 2026Review
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- Goal-directed therapy: what is the goal again?Perioperative medicine (London, England) · 2025Review
- Anticoagulation in patients with atrial fibrillation undergoing inpatient total knee arthroplasty: A matched analysis.Journal of orthopaedics · 2025Article
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- Association of intraoperative hypotension and cumulative norepinephrine dose with postoperative acute kidney injury in patients having noncardiac surgery: a retrospective cohort analysis.British journal of anaesthesia · 2025Article
- Development of a risk prediction model for acute kidney injury in liver transplant recipients.Frontiers in surgery · 2025Article
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- Comparison of Differences in Cohort (Forward) and Case Control (Backward) Methodologic Approaches for Validation of the Hypotension Prediction Index.Anesthesiology · 2024Article
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- The Effect of Intraoperative Hypotension on Postoperative Renal Function.Current anesthesiology reports · 2023Article
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- Advances of perioperative acute kidney injury in elderly patients undergoing non-cardiac surgery.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Factors associated with acute kidney injury in patients undergoing extracorporeal membrane oxygenation: retrospective cohort.Revista da Escola de Enfermagem da U S P · 2023Article
- A proposed method to minimize acute kidney injury by avoiding vasopressors during surgery.Renal failure · 2022Article
- Acute kidney injury after major orthopedic surgery: A retrospective study of frequency and related risk factors.Acta orthopaedica et traumatologica turcica · 2022Article
- Prediction of acute kidney injury in intensive care unit patients based on interpretable machine learning.Digital healthArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative hypotension is a risk factor for postoperative acute kidney injury (AKI). Elderly patients are susceptible due to reduced responses to acute hemodynamic changes.
aimsDetermine the association between hypotension identified from anesthetic charts and postoperative AKI in elderly patients.
methodsRetrospective cohort study of elective noncardiac surgery patients ≥65 years, at an Australian tertiary hospital (December 2019-March 2021), with the primary outcome of AKI ≤48 h of surgery. Factors of interest were intraoperative hypotension determined from anesthetic charts (mean arterial pressure <60 mmHg, systolic blood pressure <90 mmHg, recorded 5-min) and intraoperative vasopressor use.
resultsIn 830 patients (mean age 75 years), systolic hypotension was more frequent than mean arterial hypotension (25.7% vs. 11.9%). Most hypotensive episodes were brief (7.2% of systolic and 4.2% of mean arterial hypotension lasted >10 min) but vasopressors were used in 84.7% of cases. The incidence of postoperative AKI was 13.9%. Systolic hypotension >20 min was associated with AKI (OR, 3.88; 95% CI: 1.38-10.9), which was not significant after adjusting for vasopressors, creatinine, American Society of Anesthesiologists class, and hemoglobin drop. The cumulative dose of any specific vasopressor >20 mg (or >10 mg epinephrine) was independently associated with AKI (adjusted OR, 2.47; 95% CI: 1.34-4.58). Every 5 mg increase in the total dose of all intraoperative vasopressors used during surgery was associated with 11% increased odds of AKI (95% CI: 3-19%).
conclusionsHigh vasopressor use was associated with postoperative AKI in elderly patients undergoing noncardiac surgery, independent of hypotension identified from anesthetic charts.
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