ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2022
Distinct regulatory states control the elongation of individual skeletal rods in the sea urchin embryo.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- BMP signaling regulates dorsal skeletal growth in the sea urchin embryo.Development (Cambridge, England) · 2026Article
- Possible role of microtubules in vesicular transport of matrix protein during sea urchin larval biomineralization.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Skeletogenic Expression of Integrin Alpha, Talin and Npnt Genes and Npnt Role in Sea Urchin Skeletogenesis.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Regulatory feedback between VEGF and ERK pathways controls tip-cell expression during sea urchin skeletogenesis.Development (Cambridge, England) · 2025Article
- A mechanosensitive circuit of FAK, ROCK, and ERK controls biomineral growth and morphology in the sea urchin embryo.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Localization and origins of juvenile skeletogenic cells in the sea urchin Lytechinuspictus.Developmental biology · 2024Article
- Combinatorial regulatory states define cell fate diversity during embryogenesis.Nature communications · 2024Article
- Article
- ROCK and the actomyosin network control biomineral growth and morphology during sea urchin skeletogenesis.eLife · 2024Article
- Composite material in the sea urchinJournal of the Royal Society, Interface · 2024Article
- An optimized Tet-On system for conditional control of gene expression in sea urchins.Development (Cambridge, England) · 2023Article
- Distinct regulatory states control the elongation of individual skeletal rods in the sea urchin embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding how gene regulatory networks (GRNs) control developmental progression is a key to the mechanistic understanding of morphogenesis. The sea urchin larval skeletogenesis provides an excellent platform to tackle this question. In the early stages of sea urchin skeletogenesis, skeletogenic genes are uniformly expressed in the skeletogenic lineage. Yet, during skeletal elongation, skeletogenic genes are expressed in distinct spatial sub-domains. The regulation of differential gene expression during late skeletogenesis is not well understood.
resultsHere we reveal the dynamic expression of the skeletogenic regulatory genes that define a specific regulatory state for each pair of skeletal rods, in the sea urchin Paracentrotus lividus. The vascular endothelial growth factor (VEGF) signaling, essential for skeleton formation, specifically controls the migration of cells that form the postoral and distal anterolateral skeletogenic rods. VEGF signaling also controls the expression of regulatory genes in cells at the tips of the postoral rods, including the transcription factors Pitx1 and MyoD1. Pitx1 activity is required for normal skeletal elongation and for the expression of some of VEGF target genes.
conclusionsOur study illuminates the fine-tuning of the regulatory system during the transition from early to late skeletogenesis that gives rise to rod-specific regulatory states.
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