Evidence map›Paper›PMID 35403248›Full record

ReviewJournal of clinical laboratory analysis2022

Subversion of the immune response of human pathogenic spirochetes.

Jielite Huang, Jinlin Chen, Yafeng Xie, Zhuoran Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Subversion of the immune response of human pathogenic spirochetes.Journal of clinical laboratory analysis · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jielite HuangDepartment of Clinical Laboratory, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.ORCID https://orcid.org/0000-0002-3355-6190
Jinlin ChenDepartment of Clinical Laboratory, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.ORCID https://orcid.org/0000-0001-7402-6084
Yafeng XieDepartment of Clinical Laboratory, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Zhuoran LiuDepartment of Clinical Laboratory, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
University of South China · CN

Funding

General Funding of Hunan Provincial Health Commission 21A0282Hengyang Science and Technology Bureau Guiding Plan Project hyzdxjh202103Hunan Clinical Medical Technology Innovation and Guidance Project S2018SFYLJS0025Hunan Science and Technology Innovation Project 2018SK51504Key Funding of Hunan Provincial Education Department 202201063177 and 202211003920National Natural Science Foundation of China 81702046 and 82002182Natural Science Foundation of Hunan Province 2021JJ40479 and 2019JJ50535Postgraduate Research and Innovation Project of Hunan Province CX20190770
6 · The paper itself

Abstract

Spirochetes are a large group of prokaryotes that originated from Gram-negative bacteria and are capable of causing a variety of human and animal infections. However, the pathogenesis of spirochetes remains unclear, as different types of spirochetes play pathogenic roles through different pathogenic substances and mechanisms. To survive and spread in the host, spirochetes have evolved complicated strategies to evade host immune responses. In this review, we aimed to provide a comprehensive overview of immune evasion strategies in spirochetes infection. These strategies can be explained from the following points: (i) Antigenic variation: random, unidirectional, and segmental conversion of the gene to evade immune surveillance; (ii) Overcoming the attack of the complement system: recruitment of host complement regulators, cleavage of complement components and inhibition of complement activation to evade immune defenses; (iii) Interfering with immune cells to regulating the immune system; (iv) Persistent infection: invading and colonizing the host cell to escape immune damage.

Indexed as

Immune EvasionSpirochaetalesAnimalsComplement System ProteinsHumansImmunityComplement System Proteinsimmune evasionimmune responsepersistent infectionspirochetes

Identifiers

PMID35403248
PMCPMC9102653
OpenAlexW4223548546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.