ArticleMagnetic resonance in medicine2022
Real-time imaging of respiratory effects on cerebrospinal fluid flow in small diameter passageways.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
- Flow 2.0: A Standardized Toolbox for Real-Time Phase-Contrast MRI of Neurofluid Dynamics.Magnetic resonance in medicine · 2026Article
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Dynamic DWI detects respiratory modulation of brain parenchymal hydrodynamics.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Deep cervical lymphovenous reconstruction in Alzheimer's disease: three target-defined interfaces with distinct mechanistic implications.Frontiers in aging neuroscience · 2026Review
- Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption.Fluids and barriers of the CNS · 2025Article
- MR-Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures.Journal of magnetic resonance imaging : JMRI · 2025Review
- Region-specific drivers of CSF mobility measured with MRI in humans.Nature neuroscience · 2025Article
- Synchronous quantification of arterial, venous, and cerebrospinal fluid flow dynamics using real-time phase-contrast MRI.Fluids and barriers of the CNS · 2025Article
- Glymphatic and meningeal lymphatic dysfunction in Alzheimer's disease: Mechanisms and therapeutic perspectives.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.Interface focus · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Simultaneous and synchronous characterization of blood and CSF flow dynamics using multiple Venc PC MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Covert cerebrospinal fluid dynamics dysfunction: evolution from conventional to innovative therapies.Frontiers in neurology · 2025Review
- BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI.Fluids and barriers of the CNS · 2024Article
- CSF dynamics throughout the ventricular system using 4D flow MRI: associations to arterial pulsatility, ventricular volumes, and age.Fluids and barriers of the CNS · 2024Article
- Four-dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities.NMR in biomedicine · 2024Review
- Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration.iScience · 2024Article
- Blood and cerebrospinal fluid flow oscillations measured with real-time phase-contrast MRI: breathing mode matters.Fluids and barriers of the CNS · 2022Article
- Real-time imaging of respiratory effects on cerebrospinal fluid flow in small diameter passageways.Magnetic resonance in medicine · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRespiration-related CSF flow through the cerebral aqueduct may be useful for elucidating physiology and pathophysiology of the glymphatic system, which has been proposed as a mechanism of brain waste clearance. Therefore, we aimed to (1) develop a real-time (CSF) flow imaging method with high spatial and sufficient temporal resolution to capture respiratory effects, (2) validate the method in a phantom setup and numerical simulations, and (3) apply the method in vivo and quantify its repeatability and correlation with different respiratory conditions.
methodsA golden-angle radial flow sequence (reconstructed temporal resolution 168 ms, spatial resolution 0.6 mm) was implemented on a 7T MRI scanner and reconstructed using compressed sensing. A phantom setup mimicked simultaneous cardiac and respiratory flow oscillations. The effect of temporal resolution and vessel diameter was investigated numerically. Healthy volunteers (n = 10) were scanned at four different respiratory conditions, including repeat scans.
resultsPhantom data show that the developed sequence accurately quantifies respiratory oscillations (ratio real-time/reference Q
conclusionsThe presented real-time flow MRI method can quantify respiratory-related variations of CSF flow in the cerebral aqueduct, but it underestimates rapid cardiac oscillations. In vivo, the method showed good repeatability and a relationship between flow and respiration.
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