ArticleBrain communications2022
DNA methylation in relation to gestational age and brain dysmaturation in preterm infants.
Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review.Frontiers in artificial intelligence · 2025Pooled it
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.Biological psychiatry · 2023Pooled it
- Protein epigenetic scores derived in neonatal saliva as biomarkers of childhood cognition.Molecular psychiatry · 2026Article
- The intersection of neuroscience, socioeconomic status, and preterm birth.Pediatric research · 2026Review
- DNA Methylation ofBiological research for nursing · 2026Article
- The Peripheral Epigenome Predicts White Matter Volume Contingent on Developmental Stage: An ECHO Study.Molecular neurobiology · 2025Article
- Neonatal multimorbidity and the phenotype of premature aging in preterm infants.Pediatric research · 2025Review
- It's the little things. A framework and guidance for programs to care for infants 22-23 weeks' gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Extrauterine support of pre-term lambs achieves similar transcriptomic profiling to late pre-term lamb brains.Scientific reports · 2024Article
- Article
- Epigenetic scores derived in saliva are associated with gestational age at birth.Clinical epigenetics · 2024Article
- Red carpet moments: recognition of neuroscientists by election to UK national academies.Brain communications · 2024Article
- Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease.Frontiers in cellular neuroscience · 2024Review
- Pathomechanisms of Prenatally Programmed Adult Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight.Clinical epigenetics · 2023Article
- Applications of advanced diffusion MRI in early brain development: a comprehensive review.Brain structure & function · 2023Review
- An overview of DNA methylation-derived trait score methods and applications.Genome biology · 2023Review
- Diffuse excessive high signal intensity in the preterm brain on advanced MRI represents widespread neuropathology.NeuroImage · 2022Article
- Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age.Brain, behavior, & immunity - health · 2022Article
- Association of Pediatric Buccal Epigenetic Age Acceleration With Adverse Neonatal Brain Growth and Neurodevelopmental Outcomes Among Children Born Very Preterm With a Neonatal Infection.JAMA network open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 1 country.
Funding
Abstract
Preterm birth is associated with dysconnectivity of structural brain networks and is a leading cause of neurocognitive impairment in childhood. Variation in DNA methylation is associated with early exposure to extrauterine life but there has been little research exploring its relationship with brain development. Using genome-wide DNA methylation data from the saliva of 258 neonates, we investigated the impact of gestational age on the methylome and performed functional analysis to identify enriched gene sets from probes that contributed to differentially methylated probes or regions. We tested the hypothesis that variation in DNA methylation could underpin the association between low gestational age at birth and atypical brain development by linking differentially methylated probes with measures of white matter connectivity derived from diffusion MRI metrics: peak width skeletonized mean diffusivity, peak width skeletonized fractional anisotropy and peak width skeletonized neurite density index. Gestational age at birth was associated with widespread differential methylation at term equivalent age, with genome-wide significant associations observed for 8870 CpG probes (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.