Evidence map›Paper›PMID 35402660›Full record

ArticleEuropean journal of radiology open2022

Correlation between quantification of myocardial area at risk and ischemic burden at cardiac computed tomography.

F Y van Driest, C M Bijns, R J van der Geest, A Broersen, J Dijkstra, J W Jukema, A J H A Scholte

Abstract read
In one paragraph

Article in European journal of radiology open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

F Y van DriestDepartment of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Leiden, The Netherlands.
C M BijnsDepartment of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Leiden, The Netherlands.
R J van der GeestDepartment of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden, The Netherlands.
A BroersenDepartment of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden, The Netherlands.
J DijkstraDepartment of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden, The Netherlands.
J W JukemaDepartment of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Leiden, The Netherlands.
A J H A ScholteDepartment of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aims to investigate the correlation between myocardial area at risk at coronary computed tomography angiography (CCTA) and the ischemic burden derived from myocardial computed tomography perfusion (CTP) by using the 17-segment model. Methods: Forty-two patients with chest pain complaints who underwent a combined CCTA and CTP protocol were identified. Patients with reversible ischemia at CTP and at least one stenosis of ≥ 50% at CCTA were selected. Myocardial area at risk was calculated using a Voronoi-based segmentation algorithm at CCTA and was defined as the sum of all territories related to a ≥ 50% stenosis as a percentage of the total left ventricular (LV) mass. The latter was calculated using LV contours which were automatically drawn using a machine learning algorithm. Subsequently, the ischemic burden was defined as the number of segments demonstrating relative hypoperfusion as a percentage of the total amount of segments (=17). Finally, correlations were tested between the myocardial area at risk and the ischemic burden using Pearson's correlation coefficient. Results: A total of 77 coronary lesions were assessed. Average myocardial area at risk and ischemic burden for all lesions was 59% and 23%, respectively. Correlations for ≥ 50% and ≥ 70% stenosis based myocardial area at risk compared to ischemic burden were moderate (r = 0.564; p < 0.01) and good (r = 0.708; p < 0.01), respectively. Conclusion: The relation between myocardial area at risk as calculated by using a Voronoi-based algorithm at CCTA and ischemic burden as assessed by CTP is dependent on stenosis severity.

Indexed as

AlgorithmsAUC;, Area under the curveCAD;, Coronary artery diseaseCCTA;, Coronary computed tomography angiographyCoronary computed tomography angiographyCTP;, Computed tomography perfusionCX;, Circumflex arteryECG;, ElectrocardiogramFFR;, Fractional flow reserveLAD;, Left anterior descending arteryLV;, Left ventricleMBF;, Myocardial blood flowMRI;, Magnetic resonance imagingMyocardial area at riskMyocardial computed tomography perfusionMyocardial ischemiaRCA;, Right coronary arterySPECT;, Single photon emission computed tomographyVTK;, Visualization toolkit

Identifiers

PMID35402660
PMCPMC8983940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.