ArticleERJ open research2022
The interrelationship of chronic cough and depression: a prospective population-based study.
Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates.Annals of medicine · 2026Article
- Review
- The therapeutic effects of labetalol in chronic stress- and immuno-agonist-induced cough hypersensitivity and lung inflammation involve reducing interferon-γ-producing T lymphocytes.ERJ open research · 2026Article
- Quality of Life Impairment in Patients With Chronic Cough: How Does It Compare to Other Chronic Conditions?Allergy, asthma & immunology research · 2026Article
- Health-Related Quality of Life in Chronic Cough: A Comparative Analysis With Other Chronic Diseases.Allergy, asthma & immunology research · 2026Article
- Clinical impact and healthcare resource utilisation in patients with unexplained or refractory chronic cough: a French national population study.ERJ open research · 2026Article
- Quality of life associated with chronic cough in the multinational Burden of Obstructive Lung Disease study: a cross-sectional study.ERJ open research · 2025Article
- Cross-sectional evaluation of patients with refractory or unexplained chronic cough by office-based pulmonologists in Germany.Frontiers in medicine · 2025Article
- Exploring Traits Associated With Central Sensitization Features in Patients With Chronic Cough.Allergy, asthma & immunology research · 2024Article
- Patient-reported assessments of chronic cough in clinical trials: accessory or primary endpoints?Journal of thoracic disease · 2024Review
- Effects of the teach-back method on the health status of patients with chronic obstructive pulmonary disease: a real-world community-based cluster-randomized controlled trial.Journal of thoracic disease · 2024Article
- Article
- Patient-reported respiratory symptoms and relevant factors in patients with pulmonary nodules.Journal of thoracic disease · 2024Article
- Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study.EClinicalMedicine · 2024Article
- Article
- Article
- Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study.ERJ open research · 2023Article
- Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs-fMRI study.Thoracic cancer · 2023Article
- Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012-2021.Journal of clinical medicine · 2023Article
- Chronic Cough-Related Differences in Brain Morphometry in Adults: A Population-Based Study.Chest · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic cough is a debilitating medical condition that is often complicated by psychomorbidities such as depressive symptoms. Nevertheless, little is known about the impact of chronic cough on the risk of developing depression. Therefore, we investigated the association between chronic cough and prevalent, incident and recurrent depression in a population-based sample of middle-aged and older persons. Methods: Within the Rotterdam Study, a population-based cohort, we defined chronic cough as reporting daily coughing for ⩾3 months. Depression was assessed using the Center for Epidemiologic Studies Depression scale, clinical interviews and medical records. Associations between chronic cough and depression were determined with linear, logistic and Cox regression analyses. Results: The study included 5877 participants (mean±sd age 72±8 years, 59% female) who contributed 37 287 person-years of follow-up. At baseline, participants with chronic cough reported more depressive symptoms (adjusted standardised mean difference 0.15, 95% CI 0.07-0.22) compared to those without chronic cough. Over time, chronic cough was associated with an increased risk of depression in participants with a history of depression (hazard ratio (HR) 1.45, 95% CI 1.13-1.84), but not in those without a history of depression (HR 0.91, 95% CI 0.68-1.22). Conclusions: Adults with chronic cough have a disproportionate burden of depressive symptoms and an increased risk of recurrent depression. This highlights the importance of screening for depression in patients with chronic cough.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.