Evidence map›Paper›PMID 35402572›Full record

SynthesisFrontiers in cardiovascular medicine2022

Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention for Multivessel Coronary Artery Disease: A One-Stage Meta-Analysis.

Nicholas W S Chew, Jin Hean Koh, Cheng Han Ng, Darren Jun Hao Tan, Jie Ning Yong, Chaoxing Lin, Oliver Zi-Hern Lim, Yip Han Chin, Denzel Ming Wei Lim, Koo Hui Chan and 5 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Sex differences in survival following acute coronary syndrome with and without standard modifiable risk factors.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Pooled it
  2. Modeling Health Effects of Alternative Treatment Options during Surgical Delay to Inform Prioritization of Surgical Care.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Outcomes of myocardial revascularization in patients with obesity and multivessel coronary artery disease.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nicholas W S ChewDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Jin Hean KohYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Cheng Han NgYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Darren Jun Hao TanYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jie Ning YongYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chaoxing LinYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Oliver Zi-Hern LimYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yip Han ChinYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Denzel Ming Wei LimYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Koo Hui ChanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Poay-Huan LohDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Adrian LowDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Chi-Hang LeeDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Huay-Cheem TanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Mark ChanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Data are emerging on 10-year mortality comparing coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) with stenting for multivessel disease (MVD) without left main (LM) involvement. We conducted an updated two-stage meta-analysis using reconstructed individual patient data to compare long-term mortality between CABG and PCI for patients with MVD without significant LM coronary disease. Methods: Medline and Embase databases were searched for articles comparing CABG with PCI for MVD. A two-stage meta-analysis was conducted using reconstructed patient level survival data for all-cause mortality with subgroups by SYNTAX score. The shared-frailty and stratified Cox models were fitted to compare survival endpoints. Results: We screened 1,496 studies and included six randomized controlled trials with 7,181 patients. PCI was associated with greater 10-year all-cause mortality risk (HR: 1.282, CI: 1.118-1.469, Conclusion: This updated reconstructed individual patient-data meta-analysis revealed a sustained lower cumulative all-cause mortality of CABG over PCI for multivessel disease without LM involvement.

Indexed as

coronary arterycoronary artery bypass grafting (CABG)mortalitymultivessel coronary artery disease (MVD)percutaneous coronary intervention

Identifiers

PMID35402572
PMCPMC8990308

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.