ArticleFrontiers in cardiovascular medicine2022
Birth Weight and the Risk of Cardiovascular Outcomes: A Report From the Large Population-Based UK Biobank Cohort Study.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- DNA methylation informs adult cardiovascular risk and prevention for low birthweight individuals.Journal of global health · 2026Article
- Targeted proteomics reveal association between maternal biomarkers and child body weight in the first year of life.Journal of the Endocrine Society · 2026Article
- Care of Patients After Bariatric Surgery in the Periconceptional and Perinatal Periods.Nutrients · 2026Review
- Cardiometabolic Biomarkers at Age 44-45 in the Psychosis Spectrum: The British National Child Development Study.Schizophrenia bulletin · 2026Article
- Prenatal famine exposure restricts genetic effects on birth weight with implications for metabolic disease risk.Communications medicine · 2026Article
- Article
- Association between birth weight and chronic obstructive pulmonary disease in the UK Biobank: a prospective cohort study.BMJ open respiratory research · 2024Article
- Improving life's essential 8 mitigates myocardial infarction risk attributed to abnormal birth weight in later life.Preventive medicine reports · 2024Article
- Burden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women: An observational study.Journal of global health · 2024Observational
- Association between infant birth weight and gestational weight gain in Japanese women with diabetes mellitus.Journal of diabetes investigation · 2024Article
- Maternal weight, blood lipids, and the offspring weight trajectories during infancy and early childhood in twin pregnancies.World journal of pediatrics : WJP · 2023Article
- Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood.Communications medicine · 2023Article
- Maternal Protein Restriction in Rats Alters Postnatal Growth and Brain Lipid Sensing in Female Offspring.Nutrients · 2023Article
- Low birth weight and reduced postnatal nutrition lead to cardiac dysfunction in piglets.Journal of animal science · 2023Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
Background: Birth weight has been reported to be associated with the risk of incident cardiovascular disease (CVD); however, the relationship remains inconclusive. Here, we aimed to prospectively assess the associations between birth weight and CVD risk using the data from UK Biobank, a large-scale, prospective cohort study. Methods: We included 270,297 participants who were free of CVD at baseline and reported their birth weight for analyses. The primary outcome was incident CVD. Hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were calculated using Cox proportional hazards models adjusted for potential confounding variables. Results: During a median follow-up of 8.07 years (IQR: 7.4-8.7 years), 10,719 incident CVD events were recorded. The HRs for low birth weight vs. normal birth weight (2.5-4.0 kg) were 1.23 (95% CI: 1.09-1.38) for risk of incident CVD, 1.52 (95% CI: 1.18-1.95) for stroke, 1.33 (95% CI: 1.07-1.64) for myocardial infarction, and 1.15 (95% CI: 1.01-1.32) for CHD. For the ones with low birth weight, the risk of CVD is reduced by 11% for every kilogram of birth weight gain. The association of low birth weight with CVD was stronger among those younger than 55 years ( Conclusion: Low birth weight was associated with an increased risk of cardiovascular events. These findings highlight the longstanding consequence of low birth weight on cardiovascular system.
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Registered trials
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