SynthesisFrontiers in medicine2022
Effects of Frailty on Outcomes Following Surgery Among Patients With Hip Fractures: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Impact of frailty on postoperative complications in older adults after hip fracture: a systematic review of observational studies.Frontiers in medicine · 2025Pooled it
- Preoperative frailty and postoperative complications after non-cardiac surgery: a systematic review.The Journal of international medical research · 2024Pooled it
- Pooled it
- The impact of frailty evaluation on the risk of venous thromboembolism in patients with hip fracture following surgery: a meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Association between fall location and postoperative clinical outcomes after fragility hip fracture: a multicentre cohort study.Annals of medicine · 2026Article
- [Biological age in orthopedics : Importance, assessment, and clinical recommendations].Orthopadie (Heidelberg, Germany) · 2026Review
- In older adults undergoing surgical fixation or arthroplasty following upper limb fractures, does frailty predict post-operative complications and mortality? A systematic review and meta-analysis.JSES reviews, reports, and techniques · 2026Review
- Postoperative Complications in Patients with Frailty Syndrome Undergoing Esophagectomy-A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2026Review
- Differential association of the 5-factor modified frailty index with postoperative pulmonary complications: specific prediction of infection risk after pulmonary lobectomy.Frontiers in medicine · 2026Article
- Frailty and Time-To-Theatre for Elderly Hip Fracture Patients at a Regional Hospital in Australia: A Retrospective Cohort Study.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Modified frailty index predicts programmed cell death activation and sepsis risk after total hip arthroplasty: a retrospective cohort study.Frontiers in cell and developmental biology · 2026Article
- Dynamic frailty risk prediction in elderly hip replacement: a deep learning approach to personalized rehabilitation.BMC medical informatics and decision making · 2025Article
- Prediction of 5-Year Survival Rate After Hip Fracture Surgery Using a Comprehensive Geriatric Assessment-Based Frailty Score Model.Journal of Korean medical science · 2025Article
- Frailty and nutritional assessments for predicting postoperative complications in older adults undergoing non-cardiac surgery.Frontiers in medicine · 2025Article
- Review
- Orthogeriatric Care Following Hip Fracture: Improving Post-Operative Outcomes in an Aged Population.Life (Basel, Switzerland) · 2024Article
- Implementation of a Frailty Care Bundle (FCB) Targeting Mobilisation, Nutrition and Cognitive Engagement to Reduce Hospital Associated Decline in Older Orthopaedic Trauma Patients: Pretest-Posttest Intervention Study.Journal of frailty, sarcopenia and falls · 2024Article
- Longitudinal characteristics of physical frailty and its components in men and women post hip fracture.Journal of the American Geriatrics Society · 2024Article
- Correlation Between Anesthesia Methods and Adverse Short-Term Postoperative Outcomes Depending on Frailty: A Prospective Cohort Study.Clinical interventions in aging · 2024Observational
- Preoperative inflammatory biomarkers reveal renal involvement in postsurgical mortality in hip fracture patients: an exploratory study.Frontiers in immunology · 2024Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty is a syndrome of multisystem dysfunction in the elderly. The association between preoperative frailty and postoperative outcomes in patients with hip fractures is unclear. To address this issue, we performed a meta-analysis to determine the association of frailty with postoperative mortality, complications, and readmission in patients with hip fractures. Methods: We searched PubMed, Web of Science, Embase, and The Cochrane Library for cohort studies of frailty associated with postoperative adverse events in patients with hip fractures from inception to November 6, 2021. The Newcastle-Ottawa Scale was used to evaluate the quality of the included literature. Statistical analysis of meta-analysis was performed using Review Manager 5.3. Results: Twelve retrospective cohort studies and seven prospective cohort studies involving a total of 62,132 patients met the inclusion criteria for this meta-analysis. Compared with non-frail patients, the pooled results showed that frailty was associated with patient in-hospital mortality (relative risk [RR] = 2.93; 95% confidence intervals [CI]: 2.56-3.34), 30-day mortality (RR = 2.85, 95%CI: 1.67-4.85) and total complications (RR = 1.79, 95%CI: 1.50-2.15). Subgroup analysis showed that the type of study design and frailty assessment tool had no significant effect on the results. Sensitivity analysis showed that the polled results of frailty predicted one-year mortality and 30-day readmission was unstable. Conclusions: In this meta-analysis, we found that preoperative frailty may be associated with postoperative adverse events in patients with hip fractures, including in-hospital mortality, 30-day mortality, and postoperative complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.