Evidence map›Paper›PMID 35402292›Full record

ArticleFrontiers in cellular and infection microbiology2022

Preliminary Observation of the Changes in the Intestinal Flora of Patients With Graves' Disease Before and After Methimazole Treatment.

Mengxue Yang, Xiaodi Zheng, Yueyue Wu, Rui Zhang, Qian Yang, Zhiyan Yu, Jun Liu, Bingbing Zha, Qihai Gong, Bo Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Microbiota and Thyroid Disease: An Updated Systematic Review.Advances in experimental medicine and biology · 2023
    Pooled it
  2. Review
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  6. Association ofFrontiers in microbiology · 2026
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  10. The Impact ofPathogens (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mengxue YangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Xiaodi ZhengDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yueyue WuDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Rui ZhangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Qian YangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Zhiyan YuDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Jun LiuDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Bingbing ZhaDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Qihai GongKey Laboratory of Basic Pharmacology of the Ministry of Education, Zunyi Medical University, Zunyi, China.
Bo YangDepartment of Endocrinology, Zunyi Medical University, Zunyi, China.
Bowen SunDepartment of Endocrinology, Zunyi Medical University, Zunyi, China.
Miao ZengDepartment of Infectious Diseases I, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Fudan University · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysfunction caused by environmental factors plays an important role in the development of Graves' disease (GD), and environmental factors are closely related to the intestinal flora. Our previous study showed significant changes in the intestinal flora in GD patients compared with healthy volunteers. This study analyzed the relationships between changes in the intestinal flora, thyroid function and relevant thyroid antibodies in GD patients before and after methimazole treatment. The subjects were divided into the UGD group (18 newly diagnosed GD patients), the TGD group (10 GD patients with normal or approximately normal thyroid function after methimazole treatment) and the NC group (11 healthy volunteers). Their fresh stool samples were sent for 16S rRNA gene amplification and Illumina platform sequencing. The correlations of the relative abundance of

Indexed as

Gastrointestinal MicrobiomeGraves DiseaseFecesHumansMethimazoleRNA, Ribosomal, 16SMethimazoleRNA, Ribosomal, 16S16 rRNA gene sequencingGraves’ diseaseintestinal florashort chain fatty acidsTh17 & Treg axis

Identifiers

PMID35402292
PMCPMC8989835
OpenAlexW4220785934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.