Inhaled nitric oxide therapy for severe hypoxemia in hyperinflated mechanically ventilated bronchiolitis patient.

Alvaro DonaireGarcia, Rashmitha Dachepally, William Hanna, Samir Q Latifi, Hemant S Agarwal

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In one paragraph

Article in Respiratory medicine case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 94% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alvaro DonaireGarciaDepartment of Pediatric Critical Care, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue M-14, Cleveland, OH, 44195, USA.

Rashmitha DachepallyDepartment of Pediatric Critical Care, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue M-14, Cleveland, OH, 44195, USA.

William HannaDepartment of Pediatric Critical Care, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue M-14, Cleveland, OH, 44195, USA.

Samir Q LatifiDepartment of Pediatric Critical Care, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue M-14, Cleveland, OH, 44195, USA.

Hemant S AgarwalDepartment of Pediatric Critical Care, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue M-14, Cleveland, OH, 44195, USA.

Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Management of hospitalized bronchiolitis patients comprises supportive care including non-invasive and invasive mechanical ventilation. Inhaled nitric oxide (iNO) therapy has been used in bronchiolitis patients to manage pulmonary hypertension, acute respiratory distress syndrome, bronchoconstriction or inflammation. We report the role of iNO in management of severe hypoxemia in a 7-month-old mechanically ventilated bronchiolitis patient on 100% oxygen and high ventilator settings who had hyperinflation on chest x-ray, and diffuse bronchospasm on clinical assessment. We believe iNO improved hypoxemia in our patient by optimizing the ventilation/perfusion mismatch, decreasing dead space ventilation and relieving elevated pulmonary vascular resistance associated with alveolar overdistention. Inhaled nitric oxide therapy for severe hypoxemia in hyperinflated mechanically ventilated bronchiolitis patient.

Indexed as

BronchiolitisHyperinflationHypoxemiaMechanical ventilationNitric oxide

Identifiers

PMID35402153

DOI10.1016/j.rmcr.2022.101643

PMCPMC8987375

OpenAlexW4226049085

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.