Evidence map›Paper›PMID 35402002›Full record

ArticleVirus evolution2022

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load.

Lele Zhao, Chris Wymant, François Blanquart, Tanya Golubchik, Astrid Gall, Margreet Bakker, Daniela Bezemer, Matthew Hall, Swee Hoe Ong, Jan Albert and 18 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Lele ZhaoBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.ORCID https://orcid.org/0000-0002-2807-1914
Chris WymantBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.ORCID https://orcid.org/0000-0002-9847-8226
François BlanquartCentre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Cedex 05, Paris 75231, France.
Tanya GolubchikBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.ORCID https://orcid.org/0000-0003-2765-9828
Astrid GallEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SD, UK.
Margreet BakkerLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, MB 1007, Netherlands.
Daniela BezemerStichting HIV Monitoring, Amsterdam, Amsterdam, AZ 1105, Netherlands.
Matthew HallBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.
Swee Hoe OngWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID https://orcid.org/0000-0002-3629-5387
Jan AlbertDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Stockholm 171 77, Sweden.
Norbert BannertDivision for HIV and Other Retroviruses, Department of Infectious Diseases, Robert Koch Institute, Berlin 13353, Germany.
Jacques FellaySchool of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
M Kate GrabowskiDepartment of Pathology, John Hopkins University, Baltimore, MD 21287, USA.
Barbara Gunsenheimer-BartmeyerDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin 13353, Germany.
Huldrych F GünthardDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich CH-8091, Switzerland.
Pia KiveläDepartment of Infectious Diseases, Helsinki University Hospital, Helsinki FI-00029, Finland.
Roger D KouyosDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich CH-8091, Switzerland.
Oliver LaeyendeckerDivision of Intramural Research, NIAID, NIH, Baltimore, MD 21205, USA.
Laurence MeyerINSERM CESP U1018, Université Paris Saclay, APHP, Service de Santé Publique, Hôpital de Bicêtre, Le Kremlin-Bicêtre 94270, France.
Kholoud PorterInstitute for Global Health, University College London, London WC1N 1EH, UK.
Ard van SighemStichting HIV Monitoring, Amsterdam, Amsterdam, AZ 1105, Netherlands.ORCID https://orcid.org/0000-0002-6656-0516
Marc van der ValkStichting HIV Monitoring, Amsterdam, Amsterdam, AZ 1105, Netherlands.
Ben BerkhoutLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, MB 1007, Netherlands.ORCID https://orcid.org/0000-0002-1905-8486
Paul KellamKymab Ltd, Babraham Research Campus, Cambridge CB22 3AT, UK.
Marion CornelissenLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, MB 1007, Netherlands.
Peter ReissStichting HIV Monitoring, Amsterdam, Amsterdam, AZ 1105, Netherlands.
Christophe FraserBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.
Luca FerrettiBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
NIAID NIH HHS UM1 AI068613Wellcome Trust
6 · The paper itself

Abstract

Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising selection, with a typical optimum for the virus between 10

Indexed as

between-host evolutionHIV-1set-point viral loadtansmission fitness

Identifiers

PMID35402002
PMCPMC8986633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.