Evidence map›Paper›PMID 35401811›Full record

ArticleTheranostics2022

An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages.

Sandro Satta, Zhaojie Meng, Rebecca Hernandez, Susana Cavallero, Tong Zhou, Tzung K Hsiai, Changcheng Zhou

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Chemical & biomedical imaging · 2026
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  10. Adipocyte-Derived PXR Signaling Is Dispensable for Diet-Induced Obesity and Metabolic Disorders in Mice.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Article
  11. Article
  12. Review
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  14. Article
  15. Article
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  18. Review
  19. Nanoparticles for Coronavirus Control.Nanomaterials (Basel, Switzerland) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sandro SattaDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Zhaojie MengDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA.
Rebecca HernandezDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA.
Susana CavalleroDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Tong ZhouDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV.
Tzung K HsiaiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Changcheng ZhouDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA.
University of California, Los Angeles · USUniversity of California, Riverside · US

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Endocrine disruptor mediated activation of PXR causes dyslipidemia and atherosclerosisR01ES023470 · NIEHS · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2013 to 2022
$2.7M
Role of IKKβ in obesity and atherosclerosisR01HL131925 · NHLBI · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2016 to 2019
$1.5M
A novel mechanism for ART-associated dyslipidemia and atherosclerosisR01HL123358 · NHLBI · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2015 to 2018
$1.5M
Exercise-Induced Shear Stress Modulates Metabolic Pathways for Vascular Repair and ProtectionI01BX004356 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI HSIAI, TZUNG K · 2019 to 2024
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BLRD VA I01 BX004356NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL123358NHLBI NIH HHS R01 HL129727NHLBI NIH HHS R01 HL131925NHLBI NIH HHS R01 HL149808NIEHS NIH HHS R01 ES023470NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19 Drug TreatmentSpike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2AnimalsHumansI-kappa B KinaseInflammationLiposomesMacrophagesMiceNF-kappa BSARS-CoV-2Angiotensin-Converting Enzyme 2I-kappa B KinaseLiposomesNF-kappa BSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2IKKβ/NF-κB signalingLiposome-Human ACE2myeloid-specific IKKβ knockoutSARS-CoV-2Spike Protein

Identifiers

PMID35401811
PMCPMC8965482
OpenAlexW4225879573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.