ArticleExperimental and therapeutic medicine2022
Study of normal-tension glaucoma based on OCTA and VBM-DARTEL analysis.
Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Bibliometric and Visualized Analysis of Ophthalmic Imaging Technology for Glaucoma Diagnosis from 2015 to 2024.Journal of current ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the detection value of optical coherence tomography angiography (OCTA) and voxel-based morphometry with diffeomorphic anatomical registration through exponentiated lie algebra (VBM-DARTEL) in normal-tension glaucoma (NTG), as well as the correlation between the two functional indicators. A total of 30 patients (15 males, 15 females) with NTG and 30 (15 males, 15 females) age-, sex- and education-matched healthy controls underwent OCTA and 3.0 T MRI scanning. The OCTA technique was used to scan the optic disc area of all subjects and measure the density of blood vessels around the optic disc; 3.0 T MRI scanning was used to obtain MRI images of the brain structure and the VBM-DARTEL method was applied for image processing using Matlab7.11R2010b (MathWorks). Imaging data were compared between the groups using two-samples t-tests to identify differences in the density of blood vessels around the optic disc and the change in brain parenchyma. Correlation analysis was used to explore associations between the density of blood vessels around the optic disc and the change in brain parenchyma in NTG. The results indicated that the vascular density around the optic disc in the NTG group was significantly decreased compared with that in the control group; the vascular density was decreased with disease progression. The difference between the two groups was statistically significant (P<0.05). The VBM-DARTEL analysis indicated that the volume of the left middle frontal gyrus, right superior frontal gyrus, right precuneus, right angular gyrus and right middle occipital gyrus was decreased, whereas the volume of the right anterior central gyrus was increased. The area under the receiver operating characteristic curve for the local volume difference in brain parenchyma to predict the diagnosis of NTG was >0.7. The area of brain parenchyma reduction was positively correlated with the density of blood vessels around the optic disc (P<0.05), whereas the right anterior central gyrus was negatively correlated with vascular density. In conclusion, OCTA and VBM-DARTEL technology may facilitate non-invasive monitoring of changes in NTG structure and function, and provide non-invasive diagnostic imaging support in the early stage of the disease. These advantages are of great importance in the diagnosis and follow-up of NTG.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.