Evidence map›Paper›PMID 35401797›Full record

ArticleExperimental and therapeutic medicine2022

COVID-19 induced hypoparathyroidism: A case report.

Vasiliki Epameinondas Georgakopoulou, Pantelis Avramopoulos, Petros Papalexis, Aikaterini Bitsani, Christos Damaskos, Anna Garmpi, Maria S Venetikou, Daniel Paramythiotis, Eleni Karlafti, Pagona Sklapani and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Vasiliki Epameinondas GeorgakopoulouPulmonology Department, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Pantelis AvramopoulosFirst Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athen, 11527 Athens, Greece.
Petros PapalexisUnit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Aikaterini BitsaniFirst Department of Propedeutic and Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Christos DamaskosRenal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
Anna GarmpiFirst Department of Propedeutic and Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Maria S VenetikouLaboratory of Anatomy-Pathological Anatomy and Physiology Nutrition, Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece.
Daniel ParamythiotisFirst Propedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, 54621 Thessaloniki, Greece.
Eleni KarlaftiEmergency Department, AHEPA University Hospital, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece.
Pagona SklapaniDepartment of Cytology, Mitera Hospital, 15123 Athens, Greece.
Nikolaos TrakasDepartment of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece.
Demetrios A SpandidosLaboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Laiko General Hospital of Athens · GRNational and Kapodistrian University of Athens · GRAHEPA University Hospital · GRAristotle University of Thessaloniki · GRMitera Hospital · GRSismanoglio General Hospital · GRUniversity of Crete · GRUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low levels of serum calcium, elevated levels of serum phosphorus and absent or abnormally low levels of serum parathyroid hormone characterize hypoparathyroidism, a rare endocrine deficiency illness. Hypoparathyroidism is caused by injury to the parathyroid gland as a result of surgery or autoimmune disease. In addition, hypoparathyroidism may develop due to genetic causes or infiltrative diseases. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by multi-organ involvement, including the dysfunction of endocrine glands. Previous studies have demonstrated that SARS-CoV-2 infection induces endocrine tissue damage via various mechanisms, including direct cell damage from viral entry to the glands by binding to the angiotensin converting enzyme 2 receptors and replication, vasculitis, arterial and venous thrombosis, hypoxic cell damage, immune response and the cytokine storm. The effects of the new coronavirus, coronavirus disease 2019 (COVID-19) on the parathyroid glands have received limited attention. Hypoparathyroidism has been observed in a small number of individuals as a result of SARS-CoV-2 infection. The present study describes the case of a patient with primary hypoparathyroidism induced by COVID-19. Clinicians should also keep in mind that, despite the fact that SARS-CoV-2 has no known tropism for the parathyroid glands, it can result in primary hypoparathyroidism and decompensation of old primary hypoparathyroidism.

Indexed as

COVID-19endocrine glandshypocalcemiahypoparathyroidismparathyroid glands

Identifiers

PMID35401797
PMCPMC8988155
OpenAlexW4223482153

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.