Evidence map›Paper›PMID 35401581›Full record

ArticleFrontiers in immunology2022

Alloimmunity to Class 2 Human Leucocyte Antigens May Reduce HIV-1 Acquisition - A Nested Case-Control Study in HIV-1 Serodiscordant Couples.

Melinda S Suchard, Neil Martinson, Susan Malfeld, Debbie de Assis Rosa, Romel D Mackelprang, Jairam Lingappa, Xuanlin Hou, Helen Rees, Sinead Delany-Moretlwe, Hadassa Goldfein and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Melinda S SuchardNational Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa.
Neil MartinsonPerinatal Health Research Unit (PHRU), University of The Witwatersrand, Johannesburg, South Africa.
Susan MalfeldNational Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa.
Debbie de Assis RosaSchool of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa.
Romel D MackelprangDepartment of Global Health, University of Washington, Seattle, WA, United States.
Jairam LingappaDepartment of Global Health, University of Washington, Seattle, WA, United States.
Xuanlin HouDepartment of Global Health, University of Washington, Seattle, WA, United States.
Helen ReesWits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Sinead Delany-MoretlweWits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Hadassa GoldfeinSchool of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa.
Heena RanchodNational Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa.
David CoetzeeDivision of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Johannesburg, South Africa.
Kennedy OtwombePerinatal Health Research Unit (PHRU), University of The Witwatersrand, Johannesburg, South Africa.
Lynn MorrisNational Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa.
Caroline T TiemessenNational Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa.
Dana M SavulescuNational Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa.
University of the Witwatersrand · ZANational Health Laboratory Service · ZAUniversity of Washington · USJohns Hopkins University · USPerinatal HIV Research Unit · ZAUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enveloped viruses, including the Human Immunodeficiency Virus-1 (HIV), incorporate host proteins such as human leucocyte antigens (HLA) into their envelope. Pre-existing antibodies against HLA, termed HLA antibodies, may bind to these surface proteins and reduce viral infectivity. Related evidence includes macaque studies which suggest that xenoimmunization with HLA antigens may protect against simian immunodeficiency virus infection. Since HIV gp120 shows homology with class 2 HLA, including shared affinity for binding to CD4, class 2 HLA antibodies may influence HIV acquisition

Indexed as

HIV-1HIV InfectionsAutoantibodiesCase-Control StudiesHLA AntigensHumansAutoantibodiesHLA Antigensantibodyheterologoushighly exposed persistently seronegativeHLAMHCnon-specific

Identifiers

PMID35401581
PMCPMC8987441
OpenAlexW4220943392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.