Evidence map›Paper›PMID 35401189›Full record

ArticleFrontiers in pharmacology2022

Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model:

Fengxia Yin, Mengnan Nian, Na Wang, Hongfei Wu, Huan Wu, Wenchen Zhao, Shijian Cao, Peng Wu, An Zhou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fengxia YinThe Experimental Research Center, Anhui University of Chinese Medicine, Hefei, China.
Mengnan NianThe Experimental Research Center, Anhui University of Chinese Medicine, Hefei, China.
Na WangThe Experimental Research Center, Anhui University of Chinese Medicine, Hefei, China.
Hongfei WuSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Huan WuSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Wenchen ZhaoDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, United States.
Shijian CaoThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Peng WuAnhui Province Key Laboratory of Research and Development of Chinese Medicine, Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.
An ZhouThe Experimental Research Center, Anhui University of Chinese Medicine, Hefei, China.
Anhui University of Traditional Chinese Medicine · CNUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gandou decoction (GDD) is a classic prescription for the treatment of hepatolenticular degeneration (HLD) in China; however, the liver-protecting mechanism of this prescription needs further evaluation. In the present study, we explored the protective mechanisms of GDD in a copper-laden HLD model using integrated pharmacology and cellular metabolomics

Indexed as

cell metabolomicscopper-laden HLD hepatocyte modelgandou decoctionhepatolenticular degenerationpharmacology

Identifiers

PMID35401189
PMCPMC8984159
OpenAlexW4226218484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.