Evidence map›Paper›PMID 35401161›Full record

ArticleFrontiers in pharmacology2022

Impact of Adolescent Intermittent Ethanol Exposure on Social Investigation, Social Preference, and Neuronal Activation in cFos-LacZ Male and Female Rats.

Trevor T Towner, Devon T Applegate, Elena I Varlinskaya, David F Werner

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits.Advances in experimental medicine and biology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Trevor T TownerNeurobiology of Adolescent Drinking in Adulthood Consortium, Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY, United States.
Devon T ApplegateNeurobiology of Adolescent Drinking in Adulthood Consortium, Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY, United States.
Elena I VarlinskayaNeurobiology of Adolescent Drinking in Adulthood Consortium, Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY, United States.
David F WernerNeurobiology of Adolescent Drinking in Adulthood Consortium, Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY, United States.
Binghamton University · US

Funding

Impact of adolescent intermittent ethanol on adult social reward and anxietyU01AA019972 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI VARLINSKAYA, ELENA I, WERNER, DAVID F · 2010 to 2024
$5.4M
Development and Neuroadaptations in Alcohol and Addictions (DNA2)T32AA025606 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI J. DAVID JENTSCH · 2017 to 2026
$2.7M
Role of Neural Activity and Perineuronal Nets in Adolescent Intermittent Ethanol-Induced Social AnxietyF31AA029300 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI TOWNER, TREVOR · 2021 to 2022
$60k
NIAAA NIH HHS F31 AA029300NIAAA NIH HHS T32 AA025606NIAAA NIH HHS U01 AA019972
6 · The paper itself

Abstract

Adolescence is a sensitive developmental period during which alcohol use is often initiated and consumed in high quantities, often at binge or even high-intensity drinking levels. Our lab has repeatedly found that adolescent intermittent ethanol (AIE) exposure in rats results in long-lasting social impairments, specifically in males, however our knowledge of the neuronal underpinnings to this sex-specific effect of AIE is limited. The present study was designed to test whether social anxiety-like alterations in AIE-exposed males would be accompanied by alterations of neuronal activation across brain regions associated with social behavior, with AIE females demonstrating no social impairments and alterations in neuronal activation. Adolescent male and female cFos-LacZ transgenic rats on a Sprague-Dawley background were exposed to ethanol (4 g/kg, 25% v/v) or water

Indexed as

adolescencecfosethanol exposuresex differencessocial behaviorβgalactosidase

Identifiers

PMID35401161
PMCPMC8984146
OpenAlexW4220747008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.