Evidence map›Paper›PMID 35401134›Full record

ArticleFrontiers in behavioral neuroscience2022

Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase

Shu-Qun Shi, Carrie E Mahoney, Pavel Houdek, Wenling Zhao, Matthew P Anderson, Xinming Zhuo, Arthur Beaudet, Alena Sumova, Thomas E Scammell, Carl Hirschie Johnson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Sleep disturbance in Angelman syndrome patients.Orphanet journal of rare diseases · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Shu-Qun ShiDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Carrie E MahoneyDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Pavel HoudekLaboratory of Biological Rhythms, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Wenling ZhaoDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Matthew P AndersonDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Xinming ZhuoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.
Arthur BeaudetLuna Genetics, Inc., Houston, TX, United States.
Alena SumovaLaboratory of Biological Rhythms, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Thomas E ScammellDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Carl Hirschie JohnsonDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Beth Israel Deaconess Medical Center · USVanderbilt University · USBaylor College of Medicine · USCzech Academy of Sciences · CZCzech Academy of Sciences, Institute of Physiology · CZLuna Innovations (United States) · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Circadian and Sleep Programming in Angelman Syndrome Mouse ModelsR01NS104497 · NINDS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2017 to 2020
$1.2M
NICHD NIH HHS P50 HD103537NINDS NIH HHS R01 NS104497
6 · The paper itself

Abstract

Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene

Indexed as

Angelman syndromeautismcircadianimprintingneurodevelopmental disorderssleepUBE3A (E6AP)ubiquitin ligase

Identifiers

PMID35401134
PMCPMC8989470
OpenAlexW4221098892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.