Evidence map›Paper›PMID 35400708›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case.

Shogo Nakano, Kosuke Minaga, Yasuhiro Tani, Kohei Tonomura, Yusuke Hanawa, Hiroki Morimura, Tomoko Terashita, Hisakazu Matsumoto, Hiroyoshi Iwagami, Yasuki Nakatani and 6 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Shogo NakanoDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Kosuke MinagaDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Yasuhiro TaniDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Kohei TonomuraDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Yusuke HanawaDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Hiroki MorimuraDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Tomoko TerashitaDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Hisakazu MatsumotoDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Hiroyoshi IwagamiDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Yasuki NakataniDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Takuji AkamatsuDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Yoshito UenoyamaDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Chikara MaedaDepartment of Radiology, Japan Red Cross Wakayama Medical Center, Japan.
Kazuo OnoDepartment of Pathology, Japan Red Cross Wakayama Medical Center, Japan.
Tomohiro WatanabeDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.
Yukitaka YamashitaDepartment of Gastroenterology, Japan Red Cross Wakayama Medical Center, Japan.
Japanese Red Cross Society Wakayama Medical Center · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 82-year-old man with fever and back pain was referred to our hospital and was thus found to be thrombocytopenic. A bone marrow biopsy revealed the diffuse infiltration of poorly differentiated neuroendocrine carcinoma (NEC). Computed tomography revealed a large hepatic mass. Considering the risk of bleeding due to thrombocytopenia, a needle biopsy was not performed. The patient rapidly deteriorated and died 10 days after presentation. An autopsy confirmed the diagnosis of primary hepatic NEC, with diffuse metastasis to the spleen, bone marrow, and systemic lymph nodes. This is an extremely rare case of NEC presenting with thrombocytopenia due to extensive bone marrow and splenic infiltration.

Indexed as

AnemiaCarcinoma, NeuroendocrineThrombocytopeniaAged, 80 and overAutopsyBone MarrowHumansMaleSpleenbone marrow metastasisdisseminated carcinomatosis of the bone marrowhepatic neuroendocrine carcinomaneuroendocrine neoplasmthrombocytopenia

Identifiers

PMID35400708
PMCPMC9751712
OpenAlexW4223425079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.