Evidence map›Paper›PMID 35400264›Full record

ArticleExpert review of hematology2022

Strategies to increase access to basic sickle cell disease care in low- and middle-income countries.

Meghna Dua, Halima Bello-Manga, Yvonne M Carroll, Aisha Amal Galadanci, Umma Abdulsalam Ibrahim, Allison A King, Ayobami Olanrewaju, Jeremie H Estepp

Open access · greenAbstract read
In one paragraph

Article in Expert review of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  15. Gene Therapies for Sickle Cell Disease.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Meghna DuaDepartment of Global Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Halima Bello-MangaDepartment of Hematology and Blood Transfusion, Barau Dikko Teaching Hospital/Kaduna State University, Nigeria.
Yvonne M CarrollDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Aisha Amal GaladanciDepartment of Haematology, Aminu Kano Teaching Hospital, Kano, Nigeria.
Umma Abdulsalam IbrahimDepartment of Paediatrics, Aminu Kano Teaching Hospital, Kano, Nigeria.
Allison A Kingin Occupational Therapy, Departments of Pediatrics, Medicine and Surgery, Washington University School of MedicineProgram , St. Louis, USA.ORCID 0000-0002-1951-6176
Ayobami OlanrewajuDepartment of Global Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jeremie H EsteppDepartment of Global Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-2257-0421
St. Jude Children's Research Hospital · USAminu Kano Teaching Hospital · NGKaduna State University · NGWashington University in St. Louis · US

Funding

The Implementation of Cognitive Screening and Educational Support to Improve Outcomes of Adolescents and Young Adults with Sickle Cell Disease: From Clinic to the Community and BackU01HL133994 · NHLBI · WASHINGTON UNIVERSITY · PI KING, ALLISON A · 2016 to 2021
$5.2M
(SCANS) Sickle Cell Anemia Neurodevelopmental Screening - Mentoring and Research in Patient Oriented ResearchK24HL148305 · NHLBI · WASHINGTON UNIVERSITY · PI Allison A King · 2019 to 2026
$706k
Primary Prevention of Stroke in Children with Sickle Cell Anaemia in Nigeria: Community vs Teaching HospitalK43TW011583 · FIC · BARAU DIKKO TEACHING HOSPITAL/ KADUNA STATE UNIVERSITY · PI BELLO-MANGA, HALIMA · 2020 to 2024
$425k
FIC NIH HHS K43 TW011583NHLBI NIH HHS K24 HL148305NHLBI NIH HHS U01 HL133994
6 · The paper itself

Abstract

introductionSickle cell disease (SCD) is the most common hemoglobinopathy in the world. Over 90% of those born with SCD live in low- and middle-income countries (LMICs), yet individuals in these settings have much poorer outcomes compared to those in high-income countries. AREAS COVERED: This manuscript provides an in-depth review of the cornerstones of basic SCD care, the barriers to implementing these in LMICs, and strategies to increase access in these regions. Publications in English language, peer-reviewed, and edited from 2000 to 2021 were identified on PubMed. Google search was used for gray literature. EXPERT OPINION: Outcomes for patients with SCD in high-income countries have improved over the last few decades due to the implementation of universal newborn screening programs and use of routine antimicrobial prophylaxis, increase in therapeutic and curative options, and the adoption of specific measures to decrease risk of stroke. This success has not translated to LMICs due to several reasons including resource constraints. A combination of several strategies is needed to increase access to basic SCD care for patients in these settings.

Indexed as

Anemia, Sickle CellDeveloping CountriesHumansInfant, NewbornNeonatal ScreeningcrizanlizumabGlobal healthhydroxyureal-glutaminelow- and middle-income countriesnewborn screeningpenicillinsickle cell diseasestrokevoxelotor

Identifiers

PMID35400264
PMCPMC9442799
OpenAlexW4223434851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.