Evidence map›Paper›PMID 35400238›Full record

ArticleThe Journal of international medical research2022

Ubiquitin C-terminal hydrolase L1 promotes lymph node metastasis in small cell neuroendocrine carcinomas of the cervix.

Yunqiang Zhang, Jingxin Ding, Xuyin Zhang, Keqin Hua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yunqiang ZhangDepartment of Gynecology, The Obstetrics and Gynecology Hospital, Shanghai 200090, P.R. China.ORCID https://orcid.org/0000-0001-8668-1182
Jingxin DingDepartment of Gynecology, The Obstetrics and Gynecology Hospital, Shanghai 200090, P.R. China.ORCID https://orcid.org/0000-0003-3079-4887
Xuyin ZhangDepartment of Gynecology, The Obstetrics and Gynecology Hospital, Shanghai 200090, P.R. China.ORCID https://orcid.org/0000-0002-5949-3466
Keqin HuaDepartment of Gynecology, The Obstetrics and Gynecology Hospital, Shanghai 200090, P.R. China.ORCID https://orcid.org/0000-0001-5359-8841
Obstetrics and Gynecology Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo screen for specific differentially expressed genes in small cell neuroendocrine carcinoma of the cervix (SCNEC) and to further explore their roles and mechanisms in tumor progression.

methodsDifferentially expressed genes in SCNEC compared with squamous cell carcinoma (SCC) and adenocarcinoma (AC) were screened by microarray and immunohistochemical analyses. The biological functions of the identified genes were examined in a SCNEC cell line using RNA interference and over-expression plasmid-transfection technologies. Co-expression network analysis and immunoprecipitation technology were used to explore the potential mechanisms.

resultsCompared with SCC and AC,

conclusionUCHL1 is a potential biomarker of LNM in SCNEC. UCHL1 might promote SCNEC cell migration and invasion by reducing PROX1 ubiquitination.

Indexed as

AdenocarcinomaCarcinoma, NeuroendocrineCarcinoma, Squamous CellUbiquitin ThiolesteraseUterine Cervical NeoplasmsCell Line, TumorCell MovementCervix UteriFemaleHomeodomain ProteinsHumansLymphatic MetastasisProspero-Related Homeobox 1 ProteinTumor Suppressor ProteinsHomeodomain ProteinsProspero-Related Homeobox 1 ProteinTumor Suppressor ProteinsUbiquitin ThiolesteraseUCHL1 protein, humangene expressionlymph node metastasisnetwork analysisprospero homeobox protein 1small cell neuroendocrine carcinoma of the cervixUbiquitin C-terminal hydrolase L1

Identifiers

PMID35400238
PMCPMC9006380
OpenAlexW4223455220

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.