Evidence map›Paper›PMID 35400204›Full record

ArticleFuture oncology (London, England)2022

Plain language summary of publication: new information for the potential role of afatinib in treating people with

Jacques Cadranel

Open access · hybridAbstract readCommentPatient Education Handout
PubMed Publisher
In one paragraph

Article in Future oncology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jacques CadranelAssistance Publique Hôpitaux de Paris, Hôpital Tenon and GRC Theranoscan and Curamus Sorbonne Université, Paris, France.
THERANOSCAN : Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WHAT IS THIS SUMMARY ABOUT?: This plain language summary reports the findings of a case series, a study which evaluated a small number of people who had a certain type of cancer. This case series looked at how well a drug called afatinib worked in people who have a rare type of cancer called neuregulin-1 (also called WHAT WERE THE RESULTS?: After being treated with afatinib for up to 16 months, two people had stable disease (meaning their cancer did not get worse or improve). Three people had a partial response (meaning they showed a decrease in the size of their tumor) for over 18 months. One person had a partial response after being treated with afatinib for 11 months. WHAT DO THE RESULTS MEAN?: Afatinib showed encouraging results which suggest it may be a potential treatment for

Indexed as

LanguageLung NeoplasmsAfatinibGene FusionHumansNeuregulin-1Oncogene Proteins, FusionAfatinibNeuregulin-1NRG1 protein, humanOncogene Proteins, Fusionafatinibcase serieslay summaryNRG1NRG1 gene fusionsplain language summary

Identifiers

PMID35400204
OpenAlexW4223545302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.