ArticleJournal of the American Statistical Association2022
A multiple-testing procedure for high-dimensional mediation hypotheses.
Article in Journal of the American Statistical Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 88 citations in OpenAlex.
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- Non-invasive Vagal Nerve Stimulation as a Potential Treatment for Repetitive Blast Trauma.bioRxiv : the preprint server for biology · 2026Article
- Proteomic profiling reveals immunologic mediators of endotoxin-related lung function decline: a longitudinal prospective study in textile workers.Respiratory research · 2026Article
- A multi-omics framework for survival mediation analysis of high-dimensional proteogenomic data.PLoS computational biology · 2026Article
- BHMnet: Bayesian high-dimensional mediation analysis with network information integration for correlated mediators.Briefings in bioinformatics · 2026Article
- Epigenome-wide mediation analysis identified Cytosine-phosphate-Guanine sites linking environmental factors with diabetes indicators.Epigenomics · 2026Article
- Powerful large scale inference in high dimensional mediation analysis.PLoS computational biology · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting.Biostatistics (Oxford, England) · 2025Article
- Logica: A likelihood framework for cross-ancestry local genetic correlation estimation using summary statistics.American journal of human genetics · 2025Article
- Software Application Profile: TriplotGUI, a molecular epidemiology toolbox for investigating associations between exposures, omics, and outcomes.International journal of epidemiology · 2025Article
- High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics application.Bioinformatics (Oxford, England) · 2025Article
- Transfer learning reveals the mediating mechanisms of cross-ethnic lipid metabolic pathways in the association between APOE gene and Alzheimer's disease.Briefings in bioinformatics · 2025Article
- Large-scale composite hypothesis testing procedure for omics data analyses.NAR genomics and bioinformatics · 2025Article
- Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis.Nature medicine · 2025Article
- Debiased machine learning for ultra-high dimensional mediation analysis.Bioinformatics (Oxford, England) · 2025Article
- Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data.Annual review of statistics and its application · 2025Article
- Hypothesis Tests of Indirect Effects for Multiple Mediators.Statistical methods & applications · 2025Article
- Neighborhood environment associations with cognitive function and structural brain measures in older African Americans.BMC medicine · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods, the joint significance (JS) test yields an overly conservative type I error rate and low power, particularly for high-dimensional mediation hypotheses. In this article we develop a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of component null hypotheses and the underlying mixture null distribution of p-values. Theoretical developments and simulation experiments prove that the proposed procedure effectively controls FWER and FDR. Two mediation analyses on DNA methylation and cancer research are presented: assessing the mediation role of DNA methylation in genLetic regulation of gene expression in primary prostate cancer samples; exploring the possibility of DNA methylation mediating the effect of exercise on prostate cancer progression. Results of data examples include wellL-behaved quantile-quantile plots and improved power to detect novel mediation relationships. An R package HDMT implementing the proposed procedure is freely accessible in CRAN.
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