Observational studyFrontiers in endocrinology2022
Correlation Between Gut Microbiota and Testosterone in Male Patients With Type 2 Diabetes Mellitus.
Observational study in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Potential relationship of the gut microbiome with testosterone level in men: a systematic review.PeerJ · 2025Pooled it
- Atopic Dermatitis Beyond Cutaneous Inflammation: The Interplay Between Progesterone, Testosterone, Gut Microbiota, and Immune Dysregulation.Microorganisms · 2026Review
- Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions.International journal of molecular sciences · 2026Review
- Effects of castration on growth performance and cecal microbiota in growing raccoon dogs: an exploratory study.BMC veterinary research · 2026Article
- Probiotics as Microbiome Modulators in Male Infertility: Rethinking Dysbiosis Across the Gut-Testis Axis.Journal of personalized medicine · 2026Review
- Decoding Microbiota in Genitourinary Oncology: Biological Mechanisms and Clinical Implications-A Narrative Review.Cancers · 2026Review
- Sex-Specific Diet-Microbiota Interactions in Ageing: Implications for Healthy Longevity.Nutrients · 2025Review
- Gut microbiome-driven regulation of sex hormone homeostasis: a potential neuroendocrine connection.Gut microbes · 2025Article
- Sexual dimorphism in colon is mediated by an androgen-IL33Cell & bioscience · 2025Article
- Review
- The Effects of Wuniuzao Green Tea on Mice With High-Fat Diet-Induced Liver Steatosis.Food science & nutrition · 2025Article
- Gut Microbiota and Metabolic Dysregulation in Elderly Diabetic Patients: Is There a Gender-Specific Effect.Journal of clinical medicine · 2025Article
- Causal association of the skin microbiome with human infertility: insights from a bidirectional two-sample Mendelian randomization.Archives of dermatological research · 2025Article
- The Role of Gut Microbiota in Male Erectile Dysfunction of Rats.The world journal of men's health · 2025Article
- Changes in Gut Microbiota in Peruvian Cattle Genetic Nucleus by Breed and Correlations with Beef Quality.Veterinary sciences · 2024Article
- A Causal Relationship between Type 2 Diabetes and Candidiasis through Two-Sample Mendelian Randomization Analysis.Microorganisms · 2024Article
- Effects of Age in Fecal Microbiota and Correlations with Blood Parameters in Genetic Nucleus of Cattle.Microorganisms · 2024Article
- The Effect of Cross-Sex Fecal Microbiota Transplantation on Metabolism and Hormonal Status in Adult Rats.International journal of molecular sciences · 2024Article
- Mechanisms of microbiota-gut-brain axis communication in anxiety disorders.Frontiers in neuroscience · 2024Review
- Effects of dietary Nisin on growth performance, immune function, and gut health of broilers challenged by Clostridium perfringens.Journal of animal science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed at investigating the association between testosterone levels and gut microbiota in male patients with type 2 diabetes mellitus (T2DM) and providing a new strategy to elucidate the pathological mechanism of testosterone deficiency in T2DM patients. Methods: In an observational study including 46 T2DM male patients, the peripheral venous blood and fecal samples of all subjects were collected. The V3-V4 regions of bacterial 16S rDNA were amplified and sequenced. Alpha and beta diversities were calculated by QIIME software. The possible association between gut microbial community and clinical indicators was assessed using the Spearman correlation coefficient. The association between the relative abundance of bacteria and testosterone levels was discovered using linear regression analysis in R language. Results: There was no substantial difference in alpha and beta diversity. Conclusion: T2DM patients with testosterone deficiency have different gut microbiota compositions compared with T2DM patients alone. Low serum testosterone patients tend to have an increased abundance of opportunistic pathogens, which may be related to the occurrence and development of testosterone deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.