ArticleFrontiers in endocrinology2022
The Resting-State Brain Network Functional Connectivity Changes in Patients With Acute Thyrotoxic Myopathy Based on Independent Component Analysis.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Brain functional connectivity in hyperthyroid patients: systematic review.Frontiers in neuroscience · 2024Pooled it
- Thyroid Dysfunction and Cognitive Impairment: Neural Mechanisms and Neurofeedback-Based Interventions.Brain and behavior · 2026Review
- Independent component analysis of brain network alterations associated with cognitive impairment in coal workers' pneumoconiosis.BMC medical imaging · 2026Article
- Thyroid storm complicated by metabolic encephalopathy in a young patient: A case report and literature review.Medicine · 2025Review
- Article
- Elevated serum CD40 as a potential biomarker for the differential diagnosis of acute thyrotoxic myopathy.Scientific reports · 2025Article
- Functional decoding and meta-analytic connectivity modeling in thyroid-associated ophthalmopathy.Heliyon · 2024Article
- Abnormal static and dynamic functional network connectivity in stable chronic obstructive pulmonary disease.Frontiers in aging neuroscience · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Objective: The independent component analysis (ICA) was applied to explore the correlation between clinical manifestation and the functional connectivity changes of the sensorimotor network (SMN) and left frontoparietal network (LFPN) in patients with acute thyrotoxic myopathy (ATM), which was expected to provide a functional imaging basis for the exploration of the pathophysiological mechanism of ATM. Methods: 13 ATM patients (ATM) and 12 non-ATM patients (nATM) who met the diagnostic and inclusion criteria were enrolled. Their resting-state brain function images were obtained with resting-state functional magnetic resonance imaging (rs-fMRI). GIFT software was used for independent component analysis to obtain the brain regions with SMN and LFPN changes. The correlation between the functional connectivity of these brain regions and clinical indicators was calculated. Results: The SMN functional connectivity of ATM patients was increased at the posterior lobe of cerebellum, anterior lobe of cerebellum, right superior temporal gyrus, left cingulate gyrus, left precuneus, and left postcentral gyrus compared with that of nATM patients. However, it was decreased at the occipital lobe, right dorsolateral superior frontal gyrus, paracentral lobule, angular gyrus, and superior parietal gyrus (FDR correction, P<0.05). The LFPN functional connectivity of ATM patients was increased at the posterior lobe of cerebellum, middle temporal gyrus, inferior temporal gyrus, and right cingulate gyrus compared with that of nATM patients; but was decreased at frontal lobe, parahippocampal gyrus, precentral gyrus and postcentral gyrus (FDR correction, P<0.05) Correlation analysis results showed that the enhancement of SMN functional connection at right superior temporal gyrus was significantly negatively correlated with the free thyroxine level, and the decrease of SMN functional connectivity at occipital lobe was significantly positively correlated to the thyroid stimulating hormone level. The SMN and LFPN functional connectivity changes in other brain regions were not found to be significantly correlated with thyroid function parameters. Conclusion: The bulbar paralysis (such as dysphagia, dysarthria) in ATM patients may be related to the functional connectivity changes of resting-state SMN and LFPN. The fMRI is expected to be one of the objective imaging indicators for the early clinical intervention of ATM patients.
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