ArticleJournal of Cancer2022
MiR-211-5p Inhibits the Biological Behaviors of Colorectal Cancer via SPARC-Related Growth Factor Pathways.
Article in Journal of Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- miR-29a-3p regulates SPARC to inhibit ferroptosis and promote cell proliferation in gastric cancer.Scientific reports · 2026Article
- Has_circ_0008285/miR-211-5p/SIRT-1 Axis Suppress Ovarian Cancer Cells Progression.International journal of molecular and cellular medicine · 2023Article
Corrections and comments
- Retraction · 2022-04-26Concerns/Issues about Data · Concerns/Issues about Image · · see also: https://pubpeer.com/publications/51C522D0825763DBDCD3D1FF266DE4
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is a highly malignant cancer with poor prognosis. MiR-211-5p has been widely studied as an antioncogene; however, its function and mechanism in CRC are still unknown. This study aimed to investigate the expression patterns and biological implications of miR-211-5p in CRC. This study used quantitative real-time polymerase chain reaction to evaluate miR-211-5p expression in CRC cells and tissues. MiR-211-5p mimics were constructed to overexpress miR-211-5p in Lovo and SW480 cells. Tumor bioactivities of CRC, including cell proliferation, migration, invasion, and colony formation, were evaluated. The dual-luciferase assay was used to confirm the targeted relationship between miR-211-5p expression and secreted protein acidic and rich in cysteine (SPARC). In addition, Western blot analysis and immunohistochemical staining were used to measure SPARC, platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), and vascular endothelial growth factor (VEGF) expression levels. This study showed downregulated miR-211-5p expression in CRC cells and tissues, and this downregulation correlated with CRC progression. Meanwhile, miR-211-5p restrained CRC cell proliferation, colony formation, migration, and invasion. Mechanistically, SPARC-related growth factor pathways, including VEGF, PDGF, and TGF-β pathways, were upregulated in CRC tissues. Furthermore, SPARC acted as the target gene for miR-211-5p. Finally, SPARC overexpression suppressed the inhibitory effect of miR-211-5p on CRC cell progression. MiR-211-5p suppressed the invasion, migration, proliferation, and progression of CRC cells through sponging SPARC-related growth factor pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.