Evidence map›Paper›PMID 35399708›Full record

ArticleJournal of Cancer2022

LncRNA T-UCR Uc.339/miR-339/SLC7A11 Axis Regulates the Metastasis of Ferroptosis-Induced Lung Adenocarcinoma.

Ning Zhang, Jian Huang, Mei Xu, Yuli Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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  9. Genetic profile of ferroptosis in non-small cell lung carcinoma and pharmaceutical options for ferroptosis induction.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
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  14. Article
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  20. Regulation of Ferroptosis in Lung Adenocarcinoma.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ning ZhangDivision of Gastroenterology, Ganzhou People's Hospital, the Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi 341000, China.
Jian HuangDepartment of Hematology, Wenzhou Central Hospital, Theorem Clinical College, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Mei XuDepartment of Oncology, Ganzhou People's Hospital, the Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi 341000, China.
Yuli WangDepartment of Oncology, Ganzhou People's Hospital, the Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi 341000, China.
Ganzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung adenocarcinoma progression is closely linked to ferroptosis suppression. Emerging studies have found that the expression of its related gene SLC7A11 may be regulated by LncRNA. However, the mechanism of LncRNA in affecting the development of SLC7A11-mediated lung adenocarcinoma remains unclear. Here, we identified a Uc.339/miR-339/SLC7A11 axis that involves LncRNA T-UCR Uc.339-mediated repression of miR-339 and affects the expression of SLC7A11 to participate in tumor metastasis and development. In this study, we identified Uc.339 as upregulated in patients with lung adenocarcinoma. RAP-qPCR proved that LncRNA Uc.339 competitively binds to pri-miR-339 and inhibits the production of mature miR-339. The interaction between miR-339 and SCL7A11 was confirmed by luciferase reporter assay. The Uc.339/miR-339/SLC7A11 axis regulated the proliferation, migration and invasion of A549 and H1299cells

Indexed as

ferroptosisLncRNA T-UCRlung adenocarcinomamiR-339Uc.339

Identifiers

PMID35399708
PMCPMC8990432
OpenAlexW4225588105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.