ArticleHGG advances2022
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in HGG advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
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- Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.Reproductive biology and endocrinology : RB&E · 2025Article
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- Considerations on efforts needed to improve our understanding of the genetics of obesity.International journal of obesity (2005) · 2025Review
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- A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.Alzheimer's research & therapy · 2023Article
- Beyond borders: A commentary on the benefit of promoting immigrant populations in genome-wide association studies.HGG advances · 2023Review
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Corrections and comments
- Erratum issued
Authors and funding
116 authors at 20 institutions in 11 countries.
Lindsay Fernández-RhodesDepartment of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Victoria L BuchananDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anne E JusticeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Heather M HighlandDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Wanying ZhuVanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Hung-Hsin ChenVanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kristin L YoungDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kaustubh AdhikariSchool of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, MK7 6AA Milton Keynes, UK.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Jennifer E BelowVanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jonathan BradfieldCenter for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo 05508-220, Brazil.
LáShauntá GloverDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Daeeun KimDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Adam G LillyDepartment of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Poojan ShresthaDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Alvin G ThomasDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Xinruo ZhangDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Minhui ChenCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Sara PulitVertex Pharmaceuticals, W2 6BD Oxford, UK.
Andrea HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo 05508-220, Brazil.
Jose E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo 05508-220, Brazil.
Marta Guindo-MartínezThe Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Michael PreussThe Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Claudia SchumannHasso Plattner Institute, University of Potsdam, Digital Health Center, 14482 Potsdam, Germany.
Roelof A J SmitThe Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Gabriela Torres-MejíaDepartment of Research in Cardiovascular Diseases, Diabetes Mellitus, and Cancer, Population Health Research Center, National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico.
Victor Acuña-AlonzoNational Institute of Anthropology and History, Mexico City 06600, Mexico.
Gabriel BedoyaMolecular Genetics Investigation Group, University of Antioquia, Medellín 1226, Colombia.
Maria-Cátira BortoliniDepartment of Genetics, Federal University of Rio Grande do Sul, Porto Alegre 90040-060, Brazil.
Samuel Canizales-QuinterosPopulation Genomics Applied to Health Unit, The National Institute of Genomic Medicine and the Faculty of Chemistry at the National Autonomous University of Mexico, Mexico City 04510, Mexico.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Rolando González-JoséPatagonian Institute of the Social and Human Sciences, Patagonian National Center, Puerto Madryn U9120, Argentina.
Giovanni PolettiLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Francisco RothhammerInstitute of High Studies, University of Tarapacá, Arica 1000000, Chile.
Hakon HakonarsonCenter for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Robert IgoDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Sharon G AdlerDivision of Nephrology and Hypertension, Harbor-University of California Los Angeles Medical Center, Torrance, CA 90502, USA.
Sudha K IyengarDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Susanne B NicholasDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
George PapnicolaouNational Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Minjung KhoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Carl D LangefeldDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Lynne WagenknechtDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Roberta Mckean-CowdinDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Xiaoyi Raymond GaoDepartment of Ophthalmology and Visual Sciences, Department of Biomedical Informatics, Division of Human Genetics, The Ohio State University, Columbus, OH 43210, USA.
Darryl NousomeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
David V ContiCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Ye FengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Matthew A AllisonDepartment of Family Medicine, University of California, San Diego, CA 92161, USA.
Zorayr ArzumanyanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Thomas A BuchananDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Pauline M GenterDepartment of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yang HaiThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Willa HsuehDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Eli IppDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.
Fouad R KandeelDepartment of Translational Research & Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Kelvin LamThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Xiaohui LiThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Jerry L NadlerDepartment of Pharmacology at New York Medical College School of Medicine, Valhalla, NY 10595, USA.
Leslie J RaffelDivision of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA 92697, USA.
Kathryn RollThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Kevin SandowThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Jingyi TanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Anny H XiangResearch and Evaluation Branch, Kaiser Permanente of Southern California, Pasadena, CA 91101, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Astride Audirac-ChalifourMedical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City 06725, Mexico.
Jose de Jesus Peralta RomeroMedical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City 06725, Mexico.
Fernando HartwigPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas 96010-610, Brazil.
Bernando HortaPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas 96010-610, Brazil.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, USA.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, USA.
Ravindranath DuggiralaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, USA.
Donna E LehmanDepartment of Medicine, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Sobha PuppalaDepartment of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
Laura FejermanDepartment of Public Health Sciences, School of Medicine, and the Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
Esther M JohnDepartments of Epidemiology & Population Health and Medicine-Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Carlos Aguilar-SalinasDivision of Nutrition, Salvador Zubirán National Institute of Health Sciences and Nutrition, Mexico City 14080, Mexico.
Noël P BurttPrograms in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Jose C FlorezPrograms in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Humberto García-OrtízLaboratory of Immunogenomics and Metabolic Diseases, National Institute of Genomic Medicine, Mexico City 14610, Mexico.
Clicerio González-VillalpandoCenter for Diabetes Studies, Research Unit for Diabetes and Cardiovascular Risk, Center for Population Health Studies, National Institute of Public Health, Mexico City 14080, Mexico.
Josep MercaderPrograms in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Lorena OrozcoLaboratory of Immunogenomics and Metabolic Diseases, National Institute of Genomic Medicine, Mexico City 14610, Mexico.
Teresa Tusié-LunaMolecular Biology and Medical Genomics Unity, Institute of Biomedical Research, The National Autonomous University of Mexico and the Salvador Zubirán National Institute of Health Sciences and Nutrition, Mexico City 14080, Mexico.
Estela BlancoCenter for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA 92093, USA.
Sheila GahaganCenter for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA 92093, USA.
Nancy J CoxVanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Craig HanisUniversity of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Nancy F ButteUnited States Department of Agriculture, Agricultural Research Service, The Children's Nutrition Research Center, and the Department Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Shelley A ColePopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Anthony G ComuzzieThe Obesity Society, Silver Spring, MD 20910, USA.
V Saroja VorugantiDepartment of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA.
Rebecca RohdeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yujie WangDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Tamar SoferDiabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Elad ZivDivision of General Internal Medicine, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94115, USA.
Struan F A GrantCenter for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Andres Ruiz-LinaresMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200438, China.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Esteban J ParraDepartment of Anthropology, University of Toronto- Mississauga, Mississauga, ON L5L 1C6, Canada.
Miguel CruzMedical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City 06725, Mexico.
Ruth J F LoosThe Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USUniversity of Southern California · USHarbor–UCLA Medical Center · USUCLA Medical Center · USVanderbilt University Medical Center · USGenomics (United Kingdom) · GBChildren's Hospital of Philadelphia · USMassachusetts General Hospital · USWake Forest University · USCase Western Reserve University · USCentro Científico Tecnológico Patagónico · ARIcahn School of Medicine at Mount Sinai · USInstituto Nacional de Salud Pública · MXUniversidade de São Paulo · BRUniversidad Peruana Cayetano Heredia · PEUniversity of Washington · USAlbert Einstein College of Medicine · USCedars-Sinai Medical Center · USCity of Hope · USGeisinger Health System · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MSouthern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3MLOS ANGELES LATINO EYE STUDYU10EY011753 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 1998 to 2014
$35.6MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MPEDIGREE ANALYSIS OF LIPOPROTEIN PHENOTYPESP01HL045522 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 1991 to 2012
$27.6MCardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0MResearch Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6MGenome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MLeveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9MWhole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD RiskR01HL113323 · NHLBI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BLANGERO, JOHN, CURRAN, JOANNE E. · 2012 to 2016
$8.2MDIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0MNCATS NIH HHS UL1 TR001855NCATS NIH HHS UL1 TR001881NCI NIH HHS R01 CA063446NCI NIH HHS R01 CA204797NCI NIH HHS U01 CA261339NEI NIH HHS R01 EY014684NEI NIH HHS R01 EY022651NEI NIH HHS U10 EY011753NHGRI NIH HHS R01 HG009974NHGRI NIH HHS R01 HG010297NHGRI NIH HHS U01 HG011723NHLBI NIH HHS K99 HL130580NHLBI NIH HHS P01 HL045522NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL088457NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113323NHLBI NIH HHS R01 HL140976NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL149683NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL129982NIA NIH HHS F99 AG073565NIA NIH HHS P30 AG066615NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD056465NICHD NIH HHS R01 HD057194NICHD NIH HHS T32 HD091058NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK079888NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK118062NIDDK NIH HHS R01 DK119268NIDDK NIH HHS R01 DK122503NIGMS NIH HHS R35 GM142783
Abstract
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.
Indexed as
anthropometricsdiversityfine-mappingHispanic/Latinoobesitypopulation stratificationtrans-ancestral or trans-ethnic
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