Evidence map›Paper›PMID 35399269›Full record

ArticleFrontiers in physiology2022

A Novel Organ-Specific Approach to Selectively Target Sensory Afferents Innervating the Aortic Arch.

Khalid Elsaafien, Scott W Harden, Dominique N Johnson, Aecha K Kimball, Wanhui Sheng, Justin A Smith, Karen A Scott, Charles J Frazier, Annette D de Kloet, Eric G Krause

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. The physiology of interoception and its adaptive role in consciousness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Alleviating Hypertension by Selectively Targeting Angiotensin Receptor-Expressing Vagal Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Article
  13. Piezo1 in Digestive System Function and Dysfunction.International journal of molecular sciences · 2023
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Khalid ElsaafienDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Scott W HardenDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Dominique N JohnsonDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, United States.
Aecha K KimballDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, United States.
Wanhui ShengDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Justin A SmithDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Karen A ScottDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Charles J FrazierDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Annette D de KloetCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL, United States.
Eric G KrauseDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
University of Florida · USFlorida College of Integrative Medicine · US

Funding

Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9M
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.R01HL136595 · NHLBI · UNIVERSITY OF FLORIDA · PI COLIN SUMNERS, Annette Diane de Kloet · 2018 to 2026
$4.8M
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9M
NHLBI NIH HHS R01 HL136595NHLBI NIH HHS R01 HL145028NHLBI NIH HHS R35 HL150750
6 · The paper itself

Abstract

The brain maintains cardiovascular homeostasis, in part,

Indexed as

aortic archbaroreceptorsbaroreflexblood pressurenodose gangliasensory neuronsvagal afferents

Identifiers

PMID35399269
PMCPMC8987286
OpenAlexW4220847389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.