ReviewFrontiers in physiology2022
Mucus Clearance Strategies in Mechanically Ventilated Patients.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Catalase: A Potential Pharmacologic Target for Hydrogen Peroxide in the Treatment of COVID-19.Current topics in medicinal chemistry · 2024Pooled it
- Clinical feasibility of intratracheal tracheostomy sealing using a novel sealing disc prototype.Scientific reports · 2026Trial
- Effects of rapid chest compression technique on intracranial and cerebral perfusion pressures in acute neurocritical patients: a randomized controlled trial.Critical care (London, England) · 2025Trial
- Effects of Esketamine-Dexmedetomidine Combination on Immediate Postprocedural Oxygenation Index in Severe Pneumonia Patients Undergoing Bedside Fiberoptic Bronchoscopic Sputum Aspiration: A Prospective Randomised Controlled Trial.Drug design, development and therapy · 2025Trial
- Preoperative Professional Tooth Cleaning as a Preventive Measure for Postoperative Pneumonia in OSCC Patients: A Retrospective Study.Oral diseases · 2026Article
- Practice of airway clearance in critically ill patients: a cross-sectional survey of respiratory therapists and physiotherapists in China.Journal of thoracic disease · 2026Article
- High-frequency oscillation improves mucus clearance and airway resistance in mechanically ventilated patients: a randomized clinical trial.Annals of intensive care · 2026Article
- The impact of traumatic injury on the respiratory system; a narrative review of injury-associated and clinically-induced mechanisms of trauma-associated pneumonia.Frontiers in medicine · 2026Review
- Construction and validation of a nomogram for predicting chronic obstructive pulmonary disease with bronchiectasis.Journal of thoracic disease · 2025Article
- Managing Cough in Pediatric Neuromuscular Disorders: Lung Function and Care Strategies.Children (Basel, Switzerland) · 2025Review
- Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery.Nature communications · 2025Observational
- Article
- Causes and management of impaired gas exchange in critically ill patients.BJA education · 2025Review
- Physiology and pathophysiology of mucus and mucolytic use in critically ill patients.Critical care (London, England) · 2025Review
- A feedback-driven ventilation model for assessing airway secretions in mechanically ventilated patients.Frontiers in physiology · 2025Article
- Drug Delivery via Intrapulmonary Percussion Ventilator: Time to Follow Queen Elsa's Advice.Respiratory care · 2024Article
- Bronchiectasis Development in a Male Patient With a History of Tuberculosis: A Case Report.Cureus · 2024Article
- Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges.Nature communications · 2024Review
- Respiratory physiotherapy as a tool to allow and optimize lung donation.Respiratory medicine case reports · 2023Article
- Octreotide as a novel agent for the management of bronchorrhea in mechanically ventilated patients: A case series and review of literature.Respiratory medicine case reports · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The use of airway clearance strategies as supplementary treatment in respiratory disease has been best investigated in patients with cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (NCFBE), conditions which are traditionally characterized by excessive mucus stasis and mucociliary dysfunction. A variety of airway clearance therapies both pharmacological and non-pharmacological have been shown to ameliorate disease progression in this population and have hence been assimilated into routine respiratory care. This self-propagating cycle of mucus retention and airway damage leading to chronic inflammation and infections can also be applied to patients with respiratory failure requiring mechanical ventilation. Furthermore, excessive trachea-bronchial secretions have been associated with extubation failure presenting an opportunity for intervention. Evidence for the use of adjunctive mucoactive agents and other therapies to facilitate secretion clearance in these patients are not well defined, and this subgroup still remains largely underrepresented in clinical trials. In this review, we discuss the role of mucus clearance techniques with a proven benefit in patients with CF and NCFBE, and their potential role in patients requiring mechanical ventilation while highlighting the need for standardization and adoption of mucus clearance strategies in these patient populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.