ArticleCritical care (London, England)2022
External validation of the 2020 ERC/ESICM prognostication strategy algorithm after cardiac arrest.
Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 6. Post-cardiac arrest care.Clinical and experimental emergency medicine · 2026Guideline
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care.Intensive care medicine · 2025Guideline
- Neurofilament light chain for prognostication after cardiac arrest-first steps towards validation.Critical care (London, England) · 2025Trial
- [Out-of-hospital cardiac arrest : Current recommendations along the chain of survival and patient management].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Neuroprognostication after cardiac arrest: time-anchored reassessment and uncertainty around zero false positives.Critical care (London, England) · 2026Article
- Neuroprognostication after cardiac arrest in patients without withdrawal of life-sustaining therapy: a prospective observational multicenter study.Critical care (London, England) · 2026Observational
- Singapore Post-cardiac Arrest Care Guidelines 2026.Singapore medical journal · 2026Review
- Implementation of locally processed neuron-specific enolase is associated with improved guideline-concordant neuroprognostication after out-of-hospital cardiac arrest: a retrospective before-and-after study.Resuscitation plus · 2026Article
- [Neurological prognosis after cardiac arrest and resuscitation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Prognostic utility of somatosensory evoked potentials in supratentorial hemorrhage-induced prolonged disorders of consciousness.European journal of medical research · 2025Article
- Neuroimaging for prognosis of central nervous system infections: a systematic review and meta-analysis.Annals of intensive care · 2025Article
- The Prognosis After Cardiac Arrest: Evidence on the Short- and Long-Term Course.Deutsches Arzteblatt international · 2025Review
- Recovery Potential in Patients After Cardiac Arrest Who Die After Limitations or Withdrawal of Life Support.JAMA network open · 2025Article
- Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study.Intensive care medicine · 2024Observational
- Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal-external validation study.Critical care (London, England) · 2024Observational
- The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations.Intensive care medicine · 2024Article
- Combination strategy for prognostication in patients undergoing post-resuscitation care after cardiac arrest.Scientific reports · 2023Article
- Article
- Cortical somatosensory evoked potential amplitudes and clinical outcome after cardiac arrest: a retrospective multicenter study.Journal of neurology · 2023Article
- Sex Difference on Neurological Outcomes and Post-Cardiac Arrest Care in Out-of-Hospital Cardiac Arrest Patients Treated with Targeted Temperature Management: Post-Hoc Study of a Prospective, Multicenter, Observational Cohort Study.Journal of clinical medicine · 2023Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the performance of the post-cardiac arrest (CA) prognostication strategy algorithm recommended by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) in 2020.
methodsThis was a retrospective analysis of the Korean Hypothermia Network Prospective Registry 1.0. Unconscious patients without confounders at day 4 (72-96 h) after return of spontaneous circulation (ROSC) were included. The association between the prognostic factors included in the prognostication strategy algorithm, except status myoclonus and the neurological outcome, was investigated, and finally, the prognostic performance of the prognostication strategy algorithm was evaluated. Poor outcome was defined as cerebral performance categories 3-5 at 6 months after ROSC.
resultsA total of 660 patients were included in the final analysis. Of those, 108 (16.4%) patients had a good neurological outcome at 6 months after CA. The 2020 ERC/ESICM prognostication strategy algorithm identified patients with poor neurological outcome with 60.2% sensitivity (95% CI 55.9-64.4) and 100% specificity (95% CI 93.9-100) among patients who were unconscious or had a GCS_M score ≤ 3 and with 58.2% sensitivity (95% CI 53.9-62.3) and 100% specificity (95% CI 96.6-100) among unconscious patients. When two prognostic factors were combined, any combination of prognostic factors had a false positive rate (FPR) of 0 (95% CI 0-5.6 for combination of no PR/CR and poor CT, 0-30.8 for combination of No SSEP N20 and NSE 60).
conclusionThe 2020 ERC/ESICM prognostication strategy algorithm predicted poor outcome without an FPR and with sensitivities of 58.2-60.2%. Any combinations of two predictors recommended by ERC/ESICM showed 0% of FPR.
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