SynthesisJournal of orthopaedic surgery and research2022
Influence of the geometric and material properties of lumbar endplate on lumbar interbody fusion failure: a systematic review.
Synthesis in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Efficacy of oblique lumbar interbody fusion versus transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases: a systematic review and meta-analysis.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Experimental quantification of resistance to subsidence conferred by endplate-specific expandable implants in anterior lumbar interbody fusion.Journal of orthopaedic surgery and research · 2026Article
- Development and validation of a predictive nomogram for cage migration after posterior lumbar interbody fusion: a retrospective study of 517 patients.Frontiers in surgery · 2026Article
- Biomechanical effects of cortical bone trajectory and hybrid CBT-TT fixation on fusion-site mechanics and adjacent segment loading: a finite element study.Frontiers in bioengineering and biotechnology · 2026Article
- Efficacy of Modified Transforaminal Lumbar Interbody Fusion in Three-Planar Correction for Severe Adult Spinal Deformity: Radiographic and Clinical Outcomes.Orthopedic research and reviews · 2026Article
- The Buttress Technique, A New Maneuver to Prevent Subsidence After Thoracic and Lumbar Corpectomy.Neurosurgery practice · 2025Article
- 'Rebound Phenomenon' - a Cause of Early Cage Back-out in Transforaminal Lumbar Interbody Fusion Surgery: Insights from Case Series of 1545 Patients.Indian journal of orthopaedics · 2025Article
- Section on innovative spine research and novel technologies: fusion cage design, materials, and coatings: Science versus hype.North American Spine Society journal · 2025Article
- Development of a LASSO dynamic prediction system for interbody cage subsidence following OLIF surgery.NPJ digital medicine · 2025Article
- Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives.Bioactive materials · 2025Review
- Retrospective Analysis of Clinical Management Strategies for Cage Retropulsion Following Posterior Lumbar Interbody Fusion.Orthopaedic surgery · 2025Article
- Improved Clinical and Radiological Outcomes with Double-Cage Biportal Endoscopic Transforaminal Lumbar Interbody Fusion: A Comparative CT-Based Study.Diagnostics (Basel, Switzerland) · 2025Article
- Risk Factors for Poor Matching of Intervertebral Fusion Devices After Posterior Vertebral Column Resection in Patients With Kyphosis or Kyphoscoliosis.Orthopaedic surgery · 2025Article
- Prolonged irrigation time in endoscopic aqueous medium impairs MSC/β-TCP adhesion and osteogenic potential.Scientific reports · 2025Article
- Loosening of stand-alone ALIF versus TLIF in degenerated lumbar human spines: an in vitro biomechanical study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Higher incidence of delayed bone fusion for atlantoaxial fusion versus occipitocervical fusion with navigation system.BMC musculoskeletal disorders · 2025Article
- Augmenting Screw Technique to Prevent TLIF Cage Subsidence: A Biomechanical In Vitro Study.Bioengineering (Basel, Switzerland) · 2025Article
- The predictive value of endplate morphology and pedicle screw bone quality score on screw loosening after single-level lumbar spinal fusion surgery.Journal of orthopaedic surgery and research · 2024Article
- Tomographic Assessment of Fusion Rate, Implant-Endplate Contact Area, Subsidence, and Alignment With Lumbar Personalized Interbody Implants at 1-Year Follow-Up.International journal of spine surgery · 2024Article
- Changes in Alignment at Untreated Vertebral Levels Following Short-Segment Fusion Using Personalized Interbody Cages: Leveraging Personalized Medicine to Reduce the Risk of Reoperation.International journal of spine surgery · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLumbar interbody fusion (LIF) is an established surgical intervention for patients with leg and back pain secondary to disc herniation or degeneration. Interbody fusion involves removal of the herniated or degenerated disc and insertion of interbody devices with bone grafts into the remaining cavity. Extensive research has been conducted on operative complications such as a failure of fusion or non-union of the vertebral bodies. Multiple factors including surgical, implant, and patient factors influencing the rate of complications have been identified. Patient factors include age, sex, osteoporosis, and patient anatomy. Complications can also be influenced by the interbody cage design. The geometry of the bony endplates as well as their corresponding material properties guides the design of interbody cages, which vary considerably across patients with spinal disorders. However, studies on the effects of such variations on the rate of complications are limited. Therefore, this study aimed to perform a systematic review of lumbar endplate geometry and material property factors in LIF failure.
methodsSearch keywords included 'factor/cause for spinal fusion failure/cage subsidence/cage migration/non-union', 'lumbar', and 'interbody' in electronic databases PubMed and Scopus with no limits on year of publication.
resultsIn total, 1341 articles were reviewed, and 29 articles were deemed suitable for inclusion. Adverse events after LIF, such as cage subsidence, cage migration, and non-union, resulted in fusion failure; hence, risk factors for adverse events after LIF, notably those associated with lumbar endplate geometry and material properties, were also associated with fusion failure. Those risk factors were associated with shape, concavity, bone mineral density and stiffness of endplate, segmental disc angle, and intervertebral disc height.
conclusionsThis review demonstrated that decreased contact areas between the cage and endplate, thin and weak bony endplate as well as spinal diseases such as spondylolisthesis and osteoporosis are important causes of adverse events after LIF. These findings will facilitate the selection and design of LIF cages, including customised implants based on patient endplate properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.