Evidence map›Paper›PMID 35398967›Full record

ArticleMolecular oncology2022

Mesenchymal tumor cells drive adaptive resistance of Trp53

Linda J van Weele, Sabra I Djomehri, Shang Cai, Jane Antony, Shaheen S Sikandar, Dalong Qian, William H D Ho, Robert B West, Ferenc A Scheeren, Michael F Clarke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Linda J van WeeleInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.ORCID 0000-0003-1036-8258
Sabra I DjomehriInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
Shang CaiInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
Jane AntonyInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
Shaheen S SikandarInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
Dalong QianInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
William H D HoInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
Robert B WestDepartment Pathology, Stanford University Medical Center, Palo Alto, CA, USA.
Ferenc A ScheerenDepartment of Medical Oncology, Leiden University Medical Center, The Netherlands.
Michael F ClarkeInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, CA, USA.
California Institute for Regenerative Medicine · USCalifornia State University, Channel Islands · USLeiden University Medical Center · NLPalo Alto University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As precision medicine increases the response rate of treatment, tumors frequently bypass inhibition, and reoccur. In order for treatment to be effective long term, the mechanisms enabling treatment adaptation need to be understood. Here, we report a mouse model that, in the absence of p53 and the presence of oncogenic Kras

Indexed as

Epithelial-Mesenchymal TransitionGenes, rasAnimalsCarcinogenesisMAP Kinase Signaling SystemMiceMutationProto-Oncogene Proteins p21(ras)Signal TransductionProto-Oncogene Proteins p21(ras)breast cancerKrasmouse modeltreatment adaptation

Identifiers

PMID35398967
PMCPMC9441006
OpenAlexW4223540999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.