Evidence map›Paper›PMID 35398663›Full record

ReviewCurrent opinion in neurobiology2022

Dynamics and distribution of endosomes and lysosomes in dendrites.

Chan Choo Yap, Ashley J Mason, Bettina Winckler

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Late Endosome Transport by RILP-RAB7A Promotes Dendrite Arborization Independently of Degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Review
  6. Late endosome transport by RILP-RAB7A promotes dendrite arborization.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chan Choo YapDepartment of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Pinn Hall 3226, Charlottesville, VA 22908, USA. Electronic address: cy5x@virginia.edu.
Ashley J MasonDepartment of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Pinn Hall 3226, Charlottesville, VA 22908, USA.
Bettina WincklerDepartment of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Pinn Hall 3226, Charlottesville, VA 22908, USA. Electronic address: BWinckler@virginia.edu.
University of Virginia · US

Funding

Organization and Function of Neuronal EndosomesR01NS083378 · NINDS · UNIVERSITY OF VIRGINIA · PI Bettina R Winckler · 2013 to 2026
$5.2M
High-speed and high-resolution Zeiss880 multiphoton microscopy systemS10OD025156 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2019 to 2019
$600k
Identification of neurotrophic extracellular vesiclesR21NS111991 · NINDS · UNIVERSITY OF VIRGINIA · PI WINCKLER, BETTINA R · 2019 to 2019
$444k
NIH HHS S10 OD025156NINDS NIH HHS R01 NS083378NINDS NIH HHS R21 NS111991
6 · The paper itself

Abstract

All cells are filled with membrane-bound organelles which are responsible for the synthesis and transport as well as degradation of membrane proteins. The localization of these organelles inside cells is highly regulated. The regulation of organelle positioning has been widely studied in many cell types. In neurons, organelle positioning and its regulation is of particular interest because of the enormous size of neurons and the high spatial heterogeneity of different functional domains, such as axons, proximal and distal portions of dendrites, and synapses. We will discuss new discoveries with regard to the dynamic positioning of endosomes and lysosomes between soma and along dendrites. Just as the "how" of dynamic endosome/lysosome positioning is still being investigated, the "why" is also being explored. An exciting possibility is that synaptic activity influences organelle behaviors. We will discuss what is currently known about the how and the why of endosome/lysosome dynamics in dendrites.

Indexed as

EndosomesLysosomesAxonsDendritesNeurons

Identifiers

PMID35398663
PMCPMC9167696
OpenAlexW4223420927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.