Evidence map›Paper›PMID 35398557›Full record

ArticleThe journal of allergy and clinical immunology. In practice2022

Allergy Safety Events in Health Care: Development and Application of a Classification Schema Based on Retrospective Review.

Neelam A Phadke, Paige Wickner, Liqin Wang, Li Zhou, Elizabeth Mort, David W Bates, Claire Seguin, Xiaoqing Fu, Kimberly G Blumenthal

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Documentation of Drug and Non-Drug Allergies in Public Hospital Electronic Health Records: A National Survey.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  3. A scoping review of rule-based clinical decision support malfunctions.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  4. Latex Allergy - From Discovery to Component-resolved Diagnosis.Endocrine, metabolic & immune disorders drug targets · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neelam A PhadkeDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Massachusetts General Physicians Organization, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Boston, Mass; Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and Massachusetts General Physicians Organization, Boston, Mass. Electronic address: nphadke@partners.org.
Paige WicknerHarvard Medical School, Boston, Mass; Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
Liqin WangHarvard Medical School, Boston, Mass; Division of General Internal Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, Mass.
Li ZhouHarvard Medical School, Boston, Mass; Division of General Internal Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, Mass.
Elizabeth MortHarvard Medical School, Boston, Mass; Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and Massachusetts General Physicians Organization, Boston, Mass; Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Department of Health Care Policy, Harvard Medical School, Boston, Mass.
David W BatesHarvard Medical School, Boston, Mass; Division of General Internal Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, Mass; Harvard T.H. Chan School of Public Health, Boston, Mass.
Claire SeguinMartha's Vineyard Hospital, Oak Bluffs, Mass.
Xiaoqing FuDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; The Mongan Institute, Massachusetts General Hospital, Boston, Mass.
Kimberly G BlumenthalDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Boston, Mass; Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and Massachusetts General Physicians Organization, Boston, Mass; The Mongan Institute, Massachusetts General Hospital, Boston, Mass.

Funding

Clinical Informatics to Advance Epidemiology and Pharmacogenetics of Serious Cutaneous Adverse Drug ReactionsR01AI150295 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, LI · 2019 to 2022
$2.8M
Encoding and Processing Patient Allergy Information in EHRsR01HS022728 · AHRQ · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, LI · 2013 to 2016
$2.0M
Improving Allergy Documentation and Clinical Decision Support in the EHRR01HS025375 · AHRQ · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, LI · 2018 to 2021
$1.6M
AHRQ HHS R01 HS022728AHRQ HHS R01 HS025375NIAID NIH HHS R01 AI150295
6 · The paper itself

Abstract

backgroundAllergy safety requires understanding the operational processes that expose patients to their known allergens, including how and when such processes fail.

objectiveTo improve health care safety for patients with allergies, we developed and assessed an allergy safety event classification schema to describe failures resulting in allergy-related safety events.

methodsUsing keyword searches followed by expert manual review of 299,031 voluntarily-filed safety event reports at 2 large academic medical centers, we identified and classified allergy-related safety events from 5 years of safety reports. We used driver diagrams to elucidate root causes for commonly observed allergy safety events in health care settings.

resultsFrom 299,031 safety reports, 1922 (0.6%) were extracted with keywords and 744 (0.2%) were manually confirmed as allergy-related safety events. Safety failures were due to incomplete/inaccurate electronic health record documentation (n = 375, 50.4%), human factors (n = 175, 23.5%), allergy alert limitation and/or malfunction (n = 127, 17.1%), data exchange and interoperability failures (n = 92, 12.4%), and electronic health record system default options (n = 30, 4.0%). Safety failures resulted in known allergen exposures to drugs (n = 537), including heparin (n = 27) and topical anesthetics such as lidocaine (n = 8); latex (n = 114); food allergens (n = 73); and adhesive (n = 23).

conclusionsWe identified 744 allergy-related safety events to inform a novel safety failure classification schema as an important step toward a safer health care environment for patients with allergies. Improved systems are required to address safety issues with certain food and drug allergens.

Indexed as

Drug HypersensitivityFood HypersensitivityAllergensDelivery of Health CareDocumentationHumansRetrospective StudiesAllergensAllergy safety hazard/failureDrug allergyFood allergyPatient safety

Identifiers

PMID35398557
PMCPMC9371622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.