Evidence map›Paper›PMID 35398357›Full record

ArticleThe Journal of biological chemistry2022

Sialoglycan-binding patterns of bacterial AB

Naazneen Khan, Aniruddha Sasmal, Zahra Khedri, Patrick Secrest, Andrea Verhagen, Saurabh Srivastava, Nissi Varki, Xi Chen, Hai Yu, Travis Beddoe and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cholera toxin as a model ABArchives of toxicology · 2026
    Review
  2. Article
  3. Article
  4. Structural basis for neutralizing antibody binding to pertussis toxin.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Naazneen KhanGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Aniruddha SasmalGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Zahra KhedriGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Patrick SecrestGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Andrea VerhagenGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Saurabh SrivastavaGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Nissi VarkiGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA.
Xi ChenDepartment of Chemistry, University of California Davis, Davis, California, USA.
Hai YuDepartment of Chemistry, University of California Davis, Davis, California, USA.
Travis BeddoeDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; Department of Animal, Plant and Soil Science and Centre for Agri Bioscience (Agri Bio), La Trobe University, Bundoora, Victoria, Australia.
Adrienne W PatonDepartment of Molecular and Biomedical Science, Research Centre for Infectious Diseases, University of Adelaide, Adelaide, South Australia, Australia.
James C PatonDepartment of Molecular and Biomedical Science, Research Centre for Infectious Diseases, University of Adelaide, Adelaide, South Australia, Australia.
Ajit VarkiGlycobiology Research and Training Center, University of California San Diego, San Diego, California, USA; Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, California, USA. Electronic address: a1varki@ucsd.edu.
University of San Diego · USThe University of Adelaide · AUUniversity of California, Davis · USLa Trobe University · AUUniversity of California San Diego · US

Funding

BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
NIGMS NIH HHS R01 GM032373
6 · The paper itself

Abstract

Many pathogenic bacteria secrete AB

Indexed as

BacteriaBacterial ToxinsHost SpecificityPolysaccharidesAnimalsEvolution, MolecularMammalsN-Acetylneuraminic AcidPhylogenyPlagueProtein BindingProtein SubunitsYersinia pestisBacterial ToxinsN-Acetylneuraminic AcidPolysaccharidesProtein Subunitsbacterialcytotoxicityevolutionhost rangepathogenesisphylogeneticsialoglycan microarraytoxinYersinia pestis

Identifiers

PMID35398357
PMCPMC9120245
OpenAlexW4223507355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.