Evidence map›Paper›PMID 35398340›Full record

ArticleNeurobiology of disease2022

Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity.

David Pamies, Daphne Wiersma, Moriah E Katt, Liang Zhao, Johannes Burtscher, Georgina Harris, Lena Smirnova, Peter C Searson, Thomas Hartung, Helena T Hogberg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  8. Mapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

David PamiesCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America; Department of Biomedical Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland. Electronic address: david.pamies@unil.ch.
Daphne WiersmaCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America.
Moriah E KattDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States of America; Institute of Nanobiotechnology, 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States of America.
Liang ZhaoCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21287, United States of America.
Johannes BurtscherInstitute of Sport Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland; Department of Biomedical Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland.
Georgina HarrisCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America.
Lena SmirnovaCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America.
Peter C SearsonDepartment of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States of America; Institute of Nanobiotechnology, 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States of America.
Thomas HartungCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America; CAAT-Europe, University of Konstanz, Universitätstsr. 10, 78464 Konstanz, Germany.
Helena T HogbergCenter for Alternative to Animal Testing, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, United States of America.
Johns Hopkins University · USUniversity of Lausanne · CH

Funding

A 3D Model of Human Brain Development for Studying Gene/Environment InteractionsU18TR000547 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HARTUNG, THOMAS · 2012 to 2013
$865k
NCATS NIH HHS U18 TR000547
6 · The paper itself

Abstract

Oxidative stress is caused by an imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in brain aging and age-related neurodegenerative diseases. In the context of Parkinson's disease (PD), the sensitivity of dopaminergic neurons in the substantia nigra pars compacta to oxidative stress is considered a key factor of PD pathogenesis. Here we study the effect of different oxidative stress-inducing compounds (6-OHDA, MPTP or MPP

Indexed as

Induced Pluripotent Stem CellsParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrainDisease Models, AnimalDopaminergic NeuronsHumansMiceMice, Inbred C57BLOxidopamineReactive Oxygen SpeciesSubstantia Nigra1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineOxidopamineReactive Oxygen Species3d culture6OHDAiPSCMicrophysiological systemMPP(+)MPTPOrganoidStem cellsToxicant-induced Parkinson's disease

Identifiers

PMID35398340
PMCPMC9298686
OpenAlexW4223627748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.