ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
The impact of COVID-19 vaccines on the Case Fatality Rate: The importance of monitoring breakthrough infections.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Inferring the true number of SARS-CoV-2 infections in Japan.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Pooled it
- Article
- Article
- Immunological insights into COVID-19 in Southern Nigeria.Frontiers in immunology · 2024Article
- Case fatality rate considering the lag time from the onset of COVID-19 infection to related death from 2020 to 2022 in Japan.IJID regions · 2023Article
- COVID-19 transmission dynamics and the impact of vaccination: modelling, analysis and simulations.Royal Society open science · 2023Article
- Identifying age- and sex-specific COVID-19 mortality trends over time in six countries.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
- COVID-19 vaccination and case fatality rates: a case report in a Brazilian municipality.Cadernos de saude publica · 2023Article
- Review
- Multimorbidity and Frailty Are the Key Characteristics of Patients Hospitalized with COVID-19 Breakthrough Infection during Delta Variant Predominance in Italy: A Retrospective Study.Journal of clinical medicine · 2022Article
- Breakthrough cases of Omicron and Delta variants of SARS-CoV-2 during the fifth wave in Pakistan.Frontiers in public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to test the behavior of the case fatality rate (CFR) in a mixed population of vaccinated and unvaccinated individuals by illustrating the role of both the effectiveness of vaccines in preventing deaths and the detection of infections among both the vaccinated (breakthrough infections) and unvaccinated individuals.
methodsWe simulated three hypothetical CFR scenarios that resulted from a different combination of vaccine effectiveness in preventing deaths and the efforts in detecting infections among both the vaccinated and unvaccinated individuals.
resultsIn the presence of vaccines, the CFR depends not only on the effectiveness of vaccines in preventing deaths but also on the detection of breakthrough infections. As a result, a decline in the CFR may not imply that vaccines are effective in reducing deaths. Likewise, a constant CFR can still mean that vaccines are effective in reducing deaths.
conclusionsUnless vaccinated people are also tested for COVID-19 infection, the CFR loses its meaning in tracking the pandemic. This shows that unless efforts are directed at detecting breakthrough infections, it is hard to disentangle the effect of vaccines in reducing deaths from the probability of detecting infections on the CFR.
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Registered trials
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